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• W2012105778 abstract "<h3>Abstract</h3> The establishment of the gut microbiota immediately after birth is a dynamic process that may impact lifelong health. At this important developmental stage in early life, human milk oligosaccharides (HMOS) serve as specific substrates to promote the growth of gut microbes, particularly the group of <i>Actinobacteria</i> (bifidobacteria). Later in life, this shifts to the colonisation of <i>Firmicutes</i> and <i>Bacteroidetes</i>, which generally dominate the human gut throughout adulthood. The well-orchestrated transition is important for health, as an aberrant microbial composition and/or SCFA production are associated with colicky symptoms and atopic diseases in infants. Here, we study the trophic interactions between an HMOS-degrader, <i>Bifidobacterium longum</i> subsp. <i>infantis</i> and the butyrogenic <i>Anaerostipes caccae</i> using carbohydrate substrates that are relevant in this early life period, i.e. lactose and HMOS. Mono-and co-cultures of these bacterial species were grown at pH 6.5 in anaerobic bioreactors supplemented with lactose or total human milk carbohydrates (containing both lactose and HMOS). <i>A cac</i> was not able to grow on these substrates except when grown in co-culture with <i>B. inf</i>, leading concomitant butyrate production. Cross-feeding was observed, in which <i>A. cac</i> utilised the liberated monosaccharides as well as lactate and acetate produced by <i>B. inf</i>. This microbial cross-feeding is indicative of the key ecological role of bifidobacteria in providing substrates for other important species to colonise the infant gut. The symbiotic relationship between these key species contributes to the gradual production of butyrate early in life that could be important for host-microbial cross-talk and gut maturation. <h3>Importance</h3> The establishment of a healthy infant gut microbiota is crucial for the immune, metabolic and neurological development of infants. Recent evidence suggests that an aberrant gut microbiota early in life could lead to discomfort and predispose infants to the development of immune related diseases. This paper addresses the ecosystem function of two resident microbes of the infant gut. The significance of this research is the proof of cross-feeding interactions between HMOS-degrading bifidobacteria and a butyrate-producing microorganism. Bifidobacteria in the infant gut that support the growth and butyrogenesis of butyrate-producing bacteria, could orchestrated an important event of maturation for both the gut ecosystem and physiology of infant." @default.
• W2012105778 created "2016-06-24" @default.
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• W2012105778 date "1979-12-01" @default.
• W2012105778 modified "2023-10-16" @default.
• W2012105778 title "A study of triplets with Hashimoto's thyroiditis" @default.
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• W2012105778 doi "https://doi.org/10.1136/pgmj.55.650.894" @default.
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