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- W2012106246 abstract "In this study we explored the possibility that angiotensin-(1–7) (Ang-(1–7)) is involved in the control of blood pressure at the rostral ventrolateral medulla (RVLM) by determining the effect of angiotensin antagonists (DuP 753 and A-779) and the effect of the angiotensin converting enzyme inhibitor, ramiprilat on the pressor action produced by angiotensin I (Ang I). The pressor effect produced by bilateral microinjection of Ang I into the RVLM of anesthetized rats was not significantly altered by DuP 753 or by the ACE inhibitor ramiprilat. Conversely, the Ang-(1–7) antagonist, A-779, reduced significantly the pressor effect produced by Ang I. These data suggest that in our experimental condition Ang I was preferentially converted to Ang-(1–7) at RVLM, or that Ang I and/or one of its fragments acts through a receptor blocked by A-779." @default.
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- W2012106246 date "1996-06-01" @default.
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- W2012106246 title "Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade" @default.
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- W2012106246 doi "https://doi.org/10.1016/0162-3109(96)00049-5" @default.
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