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- W2012108135 abstract "We describe here the preparation of poly(caprolactone) (PCL)-chitin nanofibrous mats by electrospinning from a blended solution of PCL and chitin dissolved in a cosolvent, 1,1,1,3,3,3-hexafluoro-2-propanol and trifluoroacetic acid. Scanning electron microscopy showed that the neutralized PCL-chitin nanofibrous mats were morphologically stable, with a mean diameter of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>340.5</mml:mn><mml:mo>±</mml:mo><mml:mn>2.6</mml:mn></mml:mrow></mml:math> nm, compared with a diameter of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>524.2</mml:mn><mml:mo>±</mml:mo><mml:mn>12.1</mml:mn></mml:mrow></mml:math> nm for PCL mats. The nanofibrous mats showed decreased water contact angles as the proportion of chitin increased. However, the tensile properties of nanofibrous mats containing<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mn>30</mml:mn><mml:mo>~</mml:mo><mml:mn>50</mml:mn></mml:math>% (wt/wt) chitin were enhanced compared with PCL-only mats. In vitro studies showed that the viability of human dermal fibroblasts (HDFs) for up to 7 days in culture was higher on composite (OD value:<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>1.42</mml:mn><mml:mo>±</mml:mo><mml:mn>0.09</mml:mn></mml:mrow></mml:math>) than on PCL-only (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>0.51</mml:mn><mml:mo>±</mml:mo><mml:mn>0.14</mml:mn></mml:mrow></mml:math>) nanofibrous mats, with viability correlated with chitin concentration. Together, our results suggest that PCL-chitin nanofibrous mats can be used as an implantable substrate to modulate HDF viability in tissue engineering." @default.
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- W2012108135 date "2012-01-01" @default.
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- W2012108135 title "Polycaprolactone-Chitin Nanofibrous Mats as Potential Scaffolds for Tissue Engineering" @default.
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- W2012108135 doi "https://doi.org/10.1155/2012/635212" @default.
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