FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012109275> ?p ?o ?g. }

• W2012109275 endingPage "1237" @default.
• W2012109275 startingPage "1230" @default.
• W2012109275 abstract "We have previously shown that nitric oxide (NO) is involved in the hydroxyurea-induced increase of gamma-globin gene expression in cultured human erythroid progenitor cells and that hydroxyurea increases NO production in endothelial cells via endothelial NO synthase (NOS). We have now expanded those studies to demonstrate that stimulation of gamma-globin gene expression is also mediated by NOS induction in stromal cells within the bone marrow microenvironment.Using NO analyzer, we measured NO production in endothelial and macrophage cell cultures. In coculture studies of erythroid and stromal cells, we measured globin gene expression during stimulation by NO inducers.Hydroxyurea (30-100 microM) induced NOS-dependent production of NO in human macrophages (up to 1.2 microM). Coculture studies of human macrophages with erythroid progenitor cells also resulted in induction of gamma-globin mRNA expression (up to threefold) in the presence of hydroxyurea. NOS-dependent stimulation of NO by lipopolysaccharide (up to 0.6 microM) has been observed in human macrophages. We found that lipopolysaccharide and interferon-gamma together increased gamma-globin gene expression (up to twofold) in human macrophage/erythroid cell cocultures. Coculture of human bone marrow endothelial cells with erythroid progenitor cells also induced gamma-globin mRNA expression (2.4-fold) in the presence of hydroxyurea (40 microM).These results demonstrate an arrangement by which NO and fetal hemoglobin inducers may stimulate globin genes in erythroid cells via the common paracrine effect of bone marrow stromal cells." @default.
• W2012109275 created "2016-06-24" @default.
• W2012109275 creator A5010657812 @default.
• W2012109275 creator A5042122440 @default.
• W2012109275 creator A5048530830 @default.
• W2012109275 creator A5059020930 @default.
• W2012109275 creator A5076239225 @default.
• W2012109275 creator A5084311577 @default.
• W2012109275 creator A5084483479 @default.
• W2012109275 date "2009-10-01" @default.
• W2012109275 modified "2023-10-13" @default.
• W2012109275 title "Stimulated stromal cells induce γ-globin gene expression in erythroid cells via nitric oxide production" @default.
• W2012109275 cites W126895710 @default.
• W2012109275 cites W1566263009 @default.
• W2012109275 cites W171233749 @default.
• W2012109275 cites W1955659593 @default.
• W2012109275 cites W1970560179 @default.
• W2012109275 cites W1978157745 @default.
• W2012109275 cites W1988126593 @default.
• W2012109275 cites W2023287913 @default.
• W2012109275 cites W2033254313 @default.
• W2012109275 cites W2050186600 @default.
• W2012109275 cites W2060953972 @default.
• W2012109275 cites W2061188498 @default.
• W2012109275 cites W2064332148 @default.
• W2012109275 cites W2067505322 @default.
• W2012109275 cites W2076207091 @default.
• W2012109275 cites W2080867495 @default.
• W2012109275 cites W2107445650 @default.
• W2012109275 cites W2148465260 @default.
• W2012109275 cites W2335969897 @default.
• W2012109275 cites W2400797020 @default.
• W2012109275 cites W4249969224 @default.
• W2012109275 doi "https://doi.org/10.1016/j.exphem.2009.06.009" @default.
• W2012109275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2748161" @default.
• W2012109275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19576950" @default.
• W2012109275 hasPublicationYear "2009" @default.
• W2012109275 type Work @default.
• W2012109275 sameAs 2012109275 @default.
• W2012109275 citedByCount "3" @default.
• W2012109275 countsByYear W20121092752012 @default.
• W2012109275 countsByYear W20121092752014 @default.
• W2012109275 countsByYear W20121092752015 @default.
• W2012109275 crossrefType "journal-article" @default.
• W2012109275 hasAuthorship W2012109275A5010657812 @default.
• W2012109275 hasAuthorship W2012109275A5042122440 @default.
• W2012109275 hasAuthorship W2012109275A5048530830 @default.
• W2012109275 hasAuthorship W2012109275A5059020930 @default.
• W2012109275 hasAuthorship W2012109275A5076239225 @default.
• W2012109275 hasAuthorship W2012109275A5084311577 @default.
• W2012109275 hasAuthorship W2012109275A5084483479 @default.
• W2012109275 hasBestOaLocation W20121092751 @default.
• W2012109275 hasConcept C123012128 @default.
• W2012109275 hasConcept C153911025 @default.
• W2012109275 hasConcept C16930146 @default.
• W2012109275 hasConcept C170493617 @default.
• W2012109275 hasConcept C201750760 @default.
• W2012109275 hasConcept C202751555 @default.
• W2012109275 hasConcept C203014093 @default.
• W2012109275 hasConcept C2778754761 @default.
• W2012109275 hasConcept C2780007613 @default.
• W2012109275 hasConcept C28328180 @default.
• W2012109275 hasConcept C502942594 @default.
• W2012109275 hasConcept C54355233 @default.
• W2012109275 hasConcept C55493867 @default.
• W2012109275 hasConcept C7876069 @default.
• W2012109275 hasConcept C81885089 @default.
• W2012109275 hasConcept C86803240 @default.
• W2012109275 hasConcept C95444343 @default.
• W2012109275 hasConceptScore W2012109275C123012128 @default.
• W2012109275 hasConceptScore W2012109275C153911025 @default.
• W2012109275 hasConceptScore W2012109275C16930146 @default.
• W2012109275 hasConceptScore W2012109275C170493617 @default.
• W2012109275 hasConceptScore W2012109275C201750760 @default.
• W2012109275 hasConceptScore W2012109275C202751555 @default.
• W2012109275 hasConceptScore W2012109275C203014093 @default.
• W2012109275 hasConceptScore W2012109275C2778754761 @default.
• W2012109275 hasConceptScore W2012109275C2780007613 @default.
• W2012109275 hasConceptScore W2012109275C28328180 @default.
• W2012109275 hasConceptScore W2012109275C502942594 @default.
• W2012109275 hasConceptScore W2012109275C54355233 @default.
• W2012109275 hasConceptScore W2012109275C55493867 @default.
• W2012109275 hasConceptScore W2012109275C7876069 @default.
• W2012109275 hasConceptScore W2012109275C81885089 @default.
• W2012109275 hasConceptScore W2012109275C86803240 @default.
• W2012109275 hasConceptScore W2012109275C95444343 @default.
• W2012109275 hasIssue "10" @default.
• W2012109275 hasLocation W20121092751 @default.
• W2012109275 hasLocation W20121092752 @default.
• W2012109275 hasLocation W20121092753 @default.
• W2012109275 hasLocation W20121092754 @default.
• W2012109275 hasLocation W20121092755 @default.
• W2012109275 hasLocation W20121092756 @default.
• W2012109275 hasOpenAccess W2012109275 @default.
• W2012109275 hasPrimaryLocation W20121092751 @default.
• W2012109275 hasRelatedWork W1974359405 @default.
• W2012109275 hasRelatedWork W1976705720 @default.
• W2012109275 hasRelatedWork W1980757683 @default.

• next