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- W2012109934 abstract "One of the phenoxyalkanoic acid herbicides, 4-chloro-2-methylphenoxyacetic acid ethylester (MCPEE), was mixed with food and given to pregnant Wistar rats from day 8 to day 15 of gestation at levels of 40, 500, 1000 and 2000 ppm (about 2.7, 30, 60 and 100 mg/kg/day, respectively). Treatment with 2000 ppm of MCPEE resulted in decreased maternal weight gain and suppressed food consumption. No adverse fetal effect was noted at the 40 and 500 ppm levels. At the 1000 and 2000 ppm levels the fetal weight decreased, and the malformation rate increased as the dose increased. At the 2000 ppm level an increased resorption rate was observed. Major malformations produced were cleft palate, ventricular septal defect and kidney anomalies. These results indicate that MCPEE at a high dose level is embryopathic in the rat." @default.
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- W2012109934 date "1972-10-01" @default.
- W2012109934 modified "2023-09-27" @default.
- W2012109934 title "Teratogenic effects of 4-chloro-2-methylphenoxyacetic acid ethylester (MCPEE) in rats" @default.
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- W2012109934 doi "https://doi.org/10.1016/0041-008x(72)90193-7" @default.
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