FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012110463> ?p ?o ?g. }

• W2012110463 endingPage "7310" @default.
• W2012110463 startingPage "7306" @default.
• W2012110463 abstract "A reversible growth arrest of simian virus 40-transformed human fibroblasts has been produced by replacement of methionine in the growth medium by its immediate metabolic precursor, homocysteine, Although these arrested cells exhibit a greatly reduced cloning efficiency when plated in methionine-supplemented medium, they resume rapid proliferation without a lag when subconfluent cells are refed with methionine-supplemented medium. This growth arrest is accompanied by a reduction in the percentage of mitotic cells in the cell population. Furthermore, data obtained using fluorescence-activated cell sorting techniques indicate that the cells are arrested i the S and G2 phases of the cell cycle. This is in contrast to a G1-phase accumulation of cells, which occurs only in methionine-supplemented medium at very high densities and which is similar to the G1 block seen in cultures of normal fibroblasts at high density. The apparent relationship between specific events in the DNA-synthetic and premitotic phase of the cell cycle and methionine dependence in these transformed cultures is discussed." @default.
• W2012110463 created "2016-06-24" @default.
• W2012110463 creator A5007093192 @default.
• W2012110463 creator A5040819666 @default.
• W2012110463 date "1980-12-01" @default.
• W2012110463 modified "2023-10-11" @default.
• W2012110463 title "Reversible growth arrest in simian virus 40-transformed human fibroblasts." @default.
• W2012110463 cites W1594574747 @default.
• W2012110463 cites W1751468981 @default.
• W2012110463 cites W1968282348 @default.
• W2012110463 cites W1988761203 @default.
• W2012110463 cites W1994543822 @default.
• W2012110463 cites W1999839653 @default.
• W2012110463 cites W2004923380 @default.
• W2012110463 cites W2010416533 @default.
• W2012110463 cites W2012029634 @default.
• W2012110463 cites W2015122612 @default.
• W2012110463 cites W2015898183 @default.
• W2012110463 cites W2017814587 @default.
• W2012110463 cites W2029073329 @default.
• W2012110463 cites W2043678927 @default.
• W2012110463 cites W2053665669 @default.
• W2012110463 cites W2059394089 @default.
• W2012110463 cites W2062186896 @default.
• W2012110463 cites W2064670731 @default.
• W2012110463 cites W2079058985 @default.
• W2012110463 cites W2110086605 @default.
• W2012110463 cites W2126090632 @default.
• W2012110463 cites W2139283055 @default.
• W2012110463 cites W2140197654 @default.
• W2012110463 cites W2161829332 @default.
• W2012110463 doi "https://doi.org/10.1073/pnas.77.12.7306" @default.
• W2012110463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/350491" @default.
• W2012110463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6261250" @default.
• W2012110463 hasPublicationYear "1980" @default.
• W2012110463 type Work @default.
• W2012110463 sameAs 2012110463 @default.
• W2012110463 citedByCount "113" @default.
• W2012110463 countsByYear W20121104632012 @default.
• W2012110463 countsByYear W20121104632013 @default.
• W2012110463 countsByYear W20121104632014 @default.
• W2012110463 countsByYear W20121104632015 @default.
• W2012110463 countsByYear W20121104632016 @default.
• W2012110463 countsByYear W20121104632017 @default.
• W2012110463 countsByYear W20121104632018 @default.
• W2012110463 countsByYear W20121104632019 @default.
• W2012110463 countsByYear W20121104632020 @default.
• W2012110463 countsByYear W20121104632021 @default.
• W2012110463 countsByYear W20121104632022 @default.
• W2012110463 countsByYear W20121104632023 @default.
• W2012110463 crossrefType "journal-article" @default.
• W2012110463 hasAuthorship W2012110463A5007093192 @default.
• W2012110463 hasAuthorship W2012110463A5040819666 @default.
• W2012110463 hasBestOaLocation W20121104631 @default.
• W2012110463 hasConcept C104317684 @default.
• W2012110463 hasConcept C143191323 @default.
• W2012110463 hasConcept C144024400 @default.
• W2012110463 hasConcept C1491633281 @default.
• W2012110463 hasConcept C149923435 @default.
• W2012110463 hasConcept C153911025 @default.
• W2012110463 hasConcept C190474072 @default.
• W2012110463 hasConcept C2778630268 @default.
• W2012110463 hasConcept C2780912031 @default.
• W2012110463 hasConcept C2908647359 @default.
• W2012110463 hasConcept C29537977 @default.
• W2012110463 hasConcept C515207424 @default.
• W2012110463 hasConcept C552990157 @default.
• W2012110463 hasConcept C55493867 @default.
• W2012110463 hasConcept C62112901 @default.
• W2012110463 hasConcept C64241487 @default.
• W2012110463 hasConcept C85813293 @default.
• W2012110463 hasConcept C86803240 @default.
• W2012110463 hasConcept C93304396 @default.
• W2012110463 hasConcept C95444343 @default.
• W2012110463 hasConceptScore W2012110463C104317684 @default.
• W2012110463 hasConceptScore W2012110463C143191323 @default.
• W2012110463 hasConceptScore W2012110463C144024400 @default.
• W2012110463 hasConceptScore W2012110463C1491633281 @default.
• W2012110463 hasConceptScore W2012110463C149923435 @default.
• W2012110463 hasConceptScore W2012110463C153911025 @default.
• W2012110463 hasConceptScore W2012110463C190474072 @default.
• W2012110463 hasConceptScore W2012110463C2778630268 @default.
• W2012110463 hasConceptScore W2012110463C2780912031 @default.
• W2012110463 hasConceptScore W2012110463C2908647359 @default.
• W2012110463 hasConceptScore W2012110463C29537977 @default.
• W2012110463 hasConceptScore W2012110463C515207424 @default.
• W2012110463 hasConceptScore W2012110463C552990157 @default.
• W2012110463 hasConceptScore W2012110463C55493867 @default.
• W2012110463 hasConceptScore W2012110463C62112901 @default.
• W2012110463 hasConceptScore W2012110463C64241487 @default.
• W2012110463 hasConceptScore W2012110463C85813293 @default.
• W2012110463 hasConceptScore W2012110463C86803240 @default.
• W2012110463 hasConceptScore W2012110463C93304396 @default.
• W2012110463 hasConceptScore W2012110463C95444343 @default.
• W2012110463 hasIssue "12" @default.
• W2012110463 hasLocation W20121104631 @default.
• W2012110463 hasLocation W20121104632 @default.
• W2012110463 hasLocation W20121104633 @default.

• next