Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012111144> ?p ?o ?g. }
- W2012111144 endingPage "120" @default.
- W2012111144 startingPage "108" @default.
- W2012111144 abstract "We have examined the role of platelets and platelet activation, and related emerging therapeutic approaches, in acute coronary syndromes (ACS). The role of platelets in atherothrombosis and ACS is critical, since platelet activation is a key step in the manifestation of these syndromes. Adhesion of sub-endothelial collagen and von Willebrand Factor (vWF) to the glycoprotein (GP) platelet receptors (GPIaIIa and GPIb/IX/V respectively) stimulates platelet activation. During activation, platelets present pseudopodia, which ensures a tighter adhesion to the sub-endothelial matrix and, via GPIIbIIIa receptors, facilitates platelet aggregation and platelet binding to fibrinogen and vWF. Although all laboratory methods estimating platelet activation and antiplatelet therapy have specific limitations, the use of antiplatelet agents such as aspirin, clopidogrel, and GPIIbIIIa inhibitors remains essential in ACS prevention and treatment. Platelet-related genetic polymorphisms can modulate the response to these agents. Presently, antiplatelet intervention remains an important therapeutic modality, with novel antiplatelet therapies, such as prasugrel and ticagrelor under clinical investigation." @default.
- W2012111144 created "2016-06-24" @default.
- W2012111144 creator A5002979166 @default.
- W2012111144 creator A5003554644 @default.
- W2012111144 creator A5005228083 @default.
- W2012111144 creator A5084249594 @default.
- W2012111144 creator A5090768352 @default.
- W2012111144 date "2010-08-01" @default.
- W2012111144 modified "2023-09-26" @default.
- W2012111144 title "Recent therapeutic approaches to platelet activation in coronary artery disease" @default.
- W2012111144 cites W1040679560 @default.
- W2012111144 cites W141287021 @default.
- W2012111144 cites W1517556698 @default.
- W2012111144 cites W1537048205 @default.
- W2012111144 cites W1553345686 @default.
- W2012111144 cites W1559650401 @default.
- W2012111144 cites W1575525639 @default.
- W2012111144 cites W1590845064 @default.
- W2012111144 cites W1608256683 @default.
- W2012111144 cites W162836990 @default.
- W2012111144 cites W1657825487 @default.
- W2012111144 cites W1726466368 @default.
- W2012111144 cites W1790038353 @default.
- W2012111144 cites W1811402656 @default.
- W2012111144 cites W1851286093 @default.
- W2012111144 cites W1862496798 @default.
- W2012111144 cites W1939620197 @default.
- W2012111144 cites W1944642365 @default.
- W2012111144 cites W1949660470 @default.
- W2012111144 cites W196385150 @default.
- W2012111144 cites W1967580043 @default.
- W2012111144 cites W1973233314 @default.
- W2012111144 cites W1981758219 @default.
- W2012111144 cites W1984209707 @default.
- W2012111144 cites W1985491210 @default.
- W2012111144 cites W1985835171 @default.
- W2012111144 cites W1990803107 @default.
- W2012111144 cites W1997521359 @default.
- W2012111144 cites W1997582080 @default.
- W2012111144 cites W1997818250 @default.
- W2012111144 cites W1999756278 @default.
- W2012111144 cites W2000213908 @default.
- W2012111144 cites W2001688139 @default.
- W2012111144 cites W2002117798 @default.
- W2012111144 cites W2004926916 @default.
- W2012111144 cites W2005850758 @default.
- W2012111144 cites W2005875596 @default.
- W2012111144 cites W2006624707 @default.
- W2012111144 cites W2008732342 @default.
- W2012111144 cites W2011116838 @default.
- W2012111144 cites W2012761317 @default.
- W2012111144 cites W2015623521 @default.
- W2012111144 cites W2016217548 @default.
- W2012111144 cites W2016229713 @default.
- W2012111144 cites W2017445608 @default.
- W2012111144 cites W2020563114 @default.
- W2012111144 cites W2022259640 @default.
- W2012111144 cites W2024352468 @default.
- W2012111144 cites W2025605461 @default.
- W2012111144 cites W2027695939 @default.
- W2012111144 cites W2030569295 @default.
- W2012111144 cites W2032105970 @default.
- W2012111144 cites W2032994382 @default.
- W2012111144 cites W2039110378 @default.
- W2012111144 cites W2039527993 @default.
- W2012111144 cites W2039881470 @default.
- W2012111144 cites W2041694866 @default.
- W2012111144 cites W2041936661 @default.
- W2012111144 cites W2044845122 @default.
- W2012111144 cites W2052741717 @default.
- W2012111144 cites W2053379248 @default.
- W2012111144 cites W2056016201 @default.
- W2012111144 cites W2057271705 @default.
- W2012111144 cites W2058509912 @default.
- W2012111144 cites W2058874291 @default.
- W2012111144 cites W2059215195 @default.
- W2012111144 cites W2060063218 @default.
- W2012111144 cites W2060958210 @default.
- W2012111144 cites W2061975208 @default.
- W2012111144 cites W2064253758 @default.
- W2012111144 cites W2070611501 @default.
- W2012111144 cites W2070898784 @default.
- W2012111144 cites W2072518791 @default.
- W2012111144 cites W2073003630 @default.
- W2012111144 cites W2074707530 @default.
- W2012111144 cites W2076482318 @default.
- W2012111144 cites W2077401512 @default.
- W2012111144 cites W2079884282 @default.
- W2012111144 cites W2084825893 @default.
- W2012111144 cites W2088976919 @default.
- W2012111144 cites W2091705825 @default.
- W2012111144 cites W2094487117 @default.
- W2012111144 cites W2096300961 @default.
- W2012111144 cites W2099495652 @default.
- W2012111144 cites W2100209149 @default.
- W2012111144 cites W2100273384 @default.
- W2012111144 cites W2102191497 @default.
- W2012111144 cites W2103247642 @default.