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- W2012111966 startingPage "141" @default.
- W2012111966 abstract "Pharmacologic inhibition of fibroblast proliferation and scar formation remains an important consideration in many ophthalmologic surgical procedures. Such inhibition is particularly important in glaucoma filtration surgery. A sustained release system for 5-fluorouracil (5-FU) using ethylene vinyl acetate copolymer (Elvax®) was characterized In vitro. 5-FU was incorporated into Elvax discs of 4 mm diameter. Discs were coated to allow sustained and predictable release over a 14 day period. Alteration of coatings, which act as rate-controlling membranes, allowed variation in the pattern of 5-FU release from the core which acts as the drug reservoir. This system for the sustained release of 5-FU may prove valuable in glaucoma surgery where the suppression of cellular proliferation is desired. The non-inflammatory nature of Elvax suggests this compound may provide an alternative means of 5-FU delivery." @default.
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- W2012111966 date "1989-01-01" @default.
- W2012111966 modified "2023-09-25" @default.
- W2012111966 title "Sustained Release of 5-Fluorouracil from Ethylene Acetate Copolymer" @default.
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- W2012111966 doi "https://doi.org/10.1089/jop.1989.5.141" @default.
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