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- W2012112040 abstract "RACK1 is a scaffolding protein that spatially and temporally regulates numerous signaling cascades. We previously found that activation of the cAMP signaling pathway induces the translocation of RACK1 to the nucleus. We further showed that nuclear RACK1 is required to promote the transcription of the brain-derived neurotrophic factor (BDNF). Here, we set out to elucidate the mechanism underlying cAMP-dependent RACK1 nuclear translocation and BDNF transcription. We identified the scaffolding protein 14-3-3ζ as a direct binding partner of RACK1. Moreover, we found that 14-3-3ζ was necessary for the cAMP-dependent translocation of RACK1 to the nucleus. We further observed that the disruption of RACK1/14-3-3ζ interaction with a peptide derived from the RACK1/14-3-3ζ binding site or shRNA-mediated 14-3-3ζ knockdown inhibited cAMP induction of BDNF transcription. Together, these data reveal that the function of nuclear RACK1 is mediated through its interaction with 14-3-3ζ. As RACK1 and 14-3-3ζ are two multifunctional scaffolding proteins that coordinate a wide variety of signaling events, their interaction is likely to regulate other essential cellular functions." @default.
- W2012112040 created "2016-06-24" @default.
- W2012112040 creator A5005360775 @default.
- W2012112040 creator A5008613169 @default.
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- W2012112040 creator A5045031002 @default.
- W2012112040 creator A5068864529 @default.
- W2012112040 creator A5080885941 @default.
- W2012112040 date "2012-01-01" @default.
- W2012112040 modified "2023-10-17" @default.
- W2012112040 title "Direct Interaction between Scaffolding Proteins RACK1 and 14-3-3ζ Regulates Brain-derived Neurotrophic Factor (BDNF) Transcription" @default.
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- W2012112040 doi "https://doi.org/10.1074/jbc.m111.272195" @default.
- W2012112040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3249084" @default.
- W2012112040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22069327" @default.
- W2012112040 hasPublicationYear "2012" @default.
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