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• W2012112069 abstract "Quantitative tests of liver function (QTLF) which are based on the hepatic metabolism or clearance of test substances have been successfully used to predict prognosis of a variety of different liver diseases. Still sufficient data in HIV-patients under anti-retroviral therapy (ART) are lacking. Therefore, the aim of this prospective study was to investigate if and to what extent ART influences a broad panel of quantitative tests of liver function in patients with HIV-infection.Nineteen patients (14 males, 5 females, mean age 40 years) with HIV-infection underwent QTLF including lidocaine half-life test (LHT), galactose elimination capacity (GEC), and indocyanine green clearance (IGC). These tests were performed before and 3 to 6 months after initiation of anti-retroviral therapy. Twenty age-matched healthy, medication- and virus-free adults served as controls.Lidocaine half-life was significantly lower in HIV-patients without ART. Combining anti-retroviral therapies shifted cytochrome p450 activity back into standard ranges. Galactose elimination capacity as a parameter of cytosolic liver function and indocyanine green clearance as a parameter of liver perfusion were not affected by ART.QTLF may be a tool to predict prognosis or hepatic complications in HIV-infected patients with liver disease. Early determination of lidocaine half-life seems to be useful - this should be considered during the treatment of HIV-positive individuals." @default.
• W2012112069 created "2016-06-24" @default.
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• W2012112069 date "2009-01-01" @default.
• W2012112069 modified "2023-10-14" @default.
• W2012112069 title "Evaluation of quantitative liver function tests in HIV-positive patients under anti-retroviral therapy" @default.
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• W2012112069 doi "https://doi.org/10.1186/2047-783x-14-9-369" @default.
• W2012112069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3351969" @default.
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