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- W2012112920 abstract "Two methylprednisolone sodium succinate formulations with different preservatives (benzyl alcohol and parabens) and a placebo were administered in single doses of 2.0 g to 24 subjects. Both formulations were well tolerated and no important drug-related side effects were encountered. No clinically significant changes in the vital signs, electrocardiograms, electroencephalograms, or laboratory parameters were noted. All expected corticosteroid-induced changes were reversible. The higher antibacterial activity of benzyl alcohol shown in the challenge tests plus comparable tolerance to parabens favor the use of benzyl alcohol as a preservative." @default.
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- W2012112920 date "1972-09-01" @default.
- W2012112920 modified "2023-10-14" @default.
- W2012112920 title "The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects" @default.
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- W2012112920 doi "https://doi.org/10.1016/0041-008x(72)90203-7" @default.
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