FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012112938> ?p ?o ?g. }

• W2012112938 endingPage "927" @default.
• W2012112938 startingPage "921" @default.
• W2012112938 abstract "Summary: Premature newborn rabbits, delivered by hysterotomy on day 27 of gestation, were tracheotomized at birth, kept in body plethysmographs, and subjected to pressure-generated ventilation at a working pressure of 25 cm H2O, 100% O2, and frequency 40/min. Thirty-seven animals received 50 μl of heterologous surfactant (phospholipid content 40 mg/ml) via the tracheal cannula before onset of artificial ventilation, eight were ventilated with a positive end-expiratory pressure (PEEP) of 6 cm H2O, and 44 served as controls. All animals were ventilated in a randomized sequence of 2-min periods with 20, 40, 60, or 80% inspiration time. After the experiment the trachea was clamped at end-inspiration and the lungs fixed by immersion in formalin. Plethysmograph recordings of tidal volume revealed that lung-thorax compliance was low in control animals, even at inspiration time 80% (mean ± S.E. = 0.17 ± 0.03 ml/cm H2O·kg). In animals treated with surfactant or PEEP, compliance was significantly improved at all ventilator settings. The highest mean compliance values, obtained at 60% inspiration time were 0.91 ± 0.07 and 0.73 ± 0.14 ml/cm H2O·kg in surfactant- and PEEP-treated animals, respectively. Compliance of surfactant-treated animals was significantly higher than that of PEEP-treated animals at inspiration time 40% (0.85 ± 0.07 versus 0.52 ± 0.13 ml/cm H2O·kg; P < 0.05). The relative volume of the alveolar compartment, determined morphometrically in histologic sections and expressed as the alveolar expansion index (Ia), was significantly higher in surfactant-treated animals than in controls (1.60 ± 0.12 versus 0.74 ± 0.06; P < 0.005), but not improved in animals ventilated with PEEP. In animals receiving surfactant, Ia increased with the duration of the inspiration phase, from 0.99 ± 0.10 at 20% to 1.95 ± 0.22 at 80% inspiration time. There was also histologic evidence of enhanced recruitment of aerated alveoli in surfactant-treated animals ventilated with prolonged inspiration time. Speculation: The air expansion of the premature neonatal lung can be enhanced to a significant degree by treatment with surfactant in combination with appropriate prolongation of the inspiration phase. Such a therapeutic regimen might be useful in the management of newborn infants with severe respiratory distress syndrome, requiring artificial ventilation; however, because excessive prolongation of the inspiration phase could have adverse effects on pulmonary hemodynamics and lead to hypoventilation with respiratory acidosis, the setting of the ventilator should be carefully adjusted with respect to the therapeutic response in patients with respiratory distress syndrome who are treated with supplementary surfactant." @default.
• W2012112938 created "2016-06-24" @default.
• W2012112938 creator A5018212120 @default.
• W2012112938 creator A5018283823 @default.
• W2012112938 creator A5046773236 @default.
• W2012112938 creator A5048630391 @default.
• W2012112938 creator A5054001084 @default.
• W2012112938 date "1982-11-01" @default.
• W2012112938 modified "2023-09-27" @default.
• W2012112938 title "Combined Effects of Surfactant Substitution and Prolongation of Inspiration Phase in Artificially Ventilated Premature Newborn Rabbits" @default.
• W2012112938 doi "https://doi.org/10.1203/00006450-198211000-00004" @default.
• W2012112938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6760100" @default.
• W2012112938 hasPublicationYear "1982" @default.
• W2012112938 type Work @default.
• W2012112938 sameAs 2012112938 @default.
• W2012112938 citedByCount "26" @default.
• W2012112938 countsByYear W20121129382014 @default.
• W2012112938 countsByYear W20121129382015 @default.
• W2012112938 countsByYear W20121129382017 @default.
• W2012112938 crossrefType "journal-article" @default.
• W2012112938 hasAuthorship W2012112938A5018212120 @default.
• W2012112938 hasAuthorship W2012112938A5018283823 @default.
• W2012112938 hasAuthorship W2012112938A5046773236 @default.
• W2012112938 hasAuthorship W2012112938A5048630391 @default.
• W2012112938 hasAuthorship W2012112938A5054001084 @default.
• W2012112938 hasBestOaLocation W20121129381 @default.
• W2012112938 hasConcept C126322002 @default.
• W2012112938 hasConcept C127413603 @default.
• W2012112938 hasConcept C136936797 @default.
• W2012112938 hasConcept C141071460 @default.
• W2012112938 hasConcept C185592680 @default.
• W2012112938 hasConcept C200457457 @default.
• W2012112938 hasConcept C2777080012 @default.
• W2012112938 hasConcept C2777257755 @default.
• W2012112938 hasConcept C2777407945 @default.
• W2012112938 hasConcept C2777714996 @default.
• W2012112938 hasConcept C2778074680 @default.
• W2012112938 hasConcept C2779234561 @default.
• W2012112938 hasConcept C42219234 @default.
• W2012112938 hasConcept C46973012 @default.
• W2012112938 hasConcept C534529494 @default.
• W2012112938 hasConcept C54355233 @default.
• W2012112938 hasConcept C55493867 @default.
• W2012112938 hasConcept C58226133 @default.
• W2012112938 hasConcept C71924100 @default.
• W2012112938 hasConcept C73362275 @default.
• W2012112938 hasConcept C78519656 @default.
• W2012112938 hasConcept C86803240 @default.
• W2012112938 hasConceptScore W2012112938C126322002 @default.
• W2012112938 hasConceptScore W2012112938C127413603 @default.
• W2012112938 hasConceptScore W2012112938C136936797 @default.
• W2012112938 hasConceptScore W2012112938C141071460 @default.
• W2012112938 hasConceptScore W2012112938C185592680 @default.
• W2012112938 hasConceptScore W2012112938C200457457 @default.
• W2012112938 hasConceptScore W2012112938C2777080012 @default.
• W2012112938 hasConceptScore W2012112938C2777257755 @default.
• W2012112938 hasConceptScore W2012112938C2777407945 @default.
• W2012112938 hasConceptScore W2012112938C2777714996 @default.
• W2012112938 hasConceptScore W2012112938C2778074680 @default.
• W2012112938 hasConceptScore W2012112938C2779234561 @default.
• W2012112938 hasConceptScore W2012112938C42219234 @default.
• W2012112938 hasConceptScore W2012112938C46973012 @default.
• W2012112938 hasConceptScore W2012112938C534529494 @default.
• W2012112938 hasConceptScore W2012112938C54355233 @default.
• W2012112938 hasConceptScore W2012112938C55493867 @default.
• W2012112938 hasConceptScore W2012112938C58226133 @default.
• W2012112938 hasConceptScore W2012112938C71924100 @default.
• W2012112938 hasConceptScore W2012112938C73362275 @default.
• W2012112938 hasConceptScore W2012112938C78519656 @default.
• W2012112938 hasConceptScore W2012112938C86803240 @default.
• W2012112938 hasIssue "11" @default.
• W2012112938 hasLocation W20121129381 @default.
• W2012112938 hasLocation W20121129382 @default.
• W2012112938 hasOpenAccess W2012112938 @default.
• W2012112938 hasPrimaryLocation W20121129381 @default.
• W2012112938 hasRelatedWork W2007547216 @default.
• W2012112938 hasRelatedWork W2012112938 @default.
• W2012112938 hasRelatedWork W2023082917 @default.
• W2012112938 hasRelatedWork W2031382687 @default.
• W2012112938 hasRelatedWork W2093004120 @default.
• W2012112938 hasRelatedWork W2157180556 @default.
• W2012112938 hasRelatedWork W2379817976 @default.
• W2012112938 hasRelatedWork W2403893583 @default.
• W2012112938 hasRelatedWork W3085997565 @default.
• W2012112938 hasRelatedWork W3203363481 @default.
• W2012112938 hasVolume "16" @default.
• W2012112938 isParatext "false" @default.
• W2012112938 isRetracted "false" @default.
• W2012112938 magId "2012112938" @default.
• W2012112938 workType "article" @default.