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- W2012115019 abstract "The increasing resistance of pathogens to antibiotics causes a huge clinical burden that places great demands on academic researchers and the pharmaceutical industry for resolution. Antimicrobial peptides, part of native host defense, have emerged as novel potential antibiotic alternatives. Among the different classes of antimicrobial peptides, proline-rich antimicrobial peptides, predominantly sourced from insects, have been extensively investigated to study their specific modes of action. In this review, we focus on recent developments in these peptides. They show a variety of modes of actions, including mechanism shift at high concentration, non-lytic mechanisms, as well as possessing different intracellular targets and lipopolysaccharide binding activity. Furthermore, proline-rich antimicrobial peptides display the ability to not only modulate the immune system via cytokine activity or angiogenesis but also possess properties of penetrating cell membranes and crossing the blood brain barrier suggesting a role as potential novel carriers. Ongoing studies of these peptides will likely lead to the development of more potent antimicrobial peptides that may serve as important additions to the armoury of agents against bacterial infection and drug delivery." @default.
- W2012115019 created "2016-06-24" @default.
- W2012115019 creator A5016433275 @default.
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- W2012115019 creator A5047172005 @default.
- W2012115019 creator A5051860064 @default.
- W2012115019 creator A5066127571 @default.
- W2012115019 date "2014-08-21" @default.
- W2012115019 modified "2023-10-12" @default.
- W2012115019 title "Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria" @default.
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