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• W2012116247 abstract "Surface modifications of polyurethane (PU)-based implantable materials have the potential to enhance or improve hemo- or cellular-biocompatibility. In general, surface modification methods of PU have included surface treatments, physio-adsorption of desired biomolecules, and the covalent immobilization of reactive or therapeutic biomolecules. When multi-protein immobilizations are desired to mimic the enzymatic reactions found on cells and tissues, it is often necessary to design and develop surface modification strategies that will allow the co-immobilization of proteins. In this study, a surface modification strategy is presented that enables the sequential additional of proteins to a bi-dentate moiety grafted onto the PU surface. The modifications were confirmed via IR and XPS signatures. While the strategy presented is applicable to a wide variety of biomolecules, bovine serum albumin (BSA) and human immunoglobulin (hIgG) were selected as model proteins. A total immobilized protein density of 0.298 ± 0.037 μg/cm² was obtained, with nearly equal amounts of protein on each arm of the bi-dentate moiety. Proteins immobilizations were also visualized with immunofluorescent staining. Finally, the method proposed in this study was used to demonstrate a significant increase (P < 0.05) in the catalytic conversion of protein C (PC) to activated PC (APC) using sequentially immobilized thrombomodulin (TM) and endothelial PC receptor (EPCR) as compared to the two proteins immobilized onto a surface in random order." @default.
• W2012116247 created "2016-06-24" @default.
• W2012116247 creator A5042654570 @default.
• W2012116247 creator A5056029015 @default.
• W2012116247 date "2011-01-01" @default.
• W2012116247 modified "2023-09-27" @default.
• W2012116247 title "Surface Modification of Biomedical Grade Polyurethane to Enable the Ordered Co-immobilization of Two Proteins" @default.
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• W2012116247 doi "https://doi.org/10.1163/092050610x529191" @default.
• W2012116247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21047446" @default.
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