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• W2012117729 abstract "The accuracy and reproducibility of deformable image registration (DIR) is central to the use of multimodality imaging to improve RT target definition. Validation of DIR is essential prior to clinical implementation. A multimodality imaging study is ongoing at our institution to investigate the role of MRI in volume delineation for head and neck cancer. A number of software packages are available for multimodality DIR, the aim of the current study is to assess the accuracy and reproducibility of one such package. Five patients had a planning CT (pCT) (resolution 1.4x1.4x2.5mm) and T1-weighted MRI scans both with (iMR) and without (MR) immobilization (resolution 0.9x0.9x2mm). The accuracy of the DIR compounded over different registration types was tested by assessing registrations in a closed loop. For all patients a single observer registered 3 steps: pCT - iMR; iMR - MR; and MR - pCT. The start and end of this registration are the same so any difference gives information on the compounded accuracy of different DIR types. Reproducibility of the DIR was assessed on each step of the closed loop separately. To assess inter-observer reproducibility 4 observers registered each of the 3 steps separately for 3 patients. To assess intra-observer reproducibility the pCT - iMR for 3 patients were registered by each observer on 3 occasions (separated by 24hrs). All registrations were performed and involved 3 steps: manual rigid body, automatic rigid body and automatic DIR. Registrations were assessed by propagating 3 spheres (3cm diameter) in different anatomical regions. Propagated spheres were compared with the dice similarity coefficient (DSC) and mean distance to agreement (MDA). All mean DSC and MDA results are shown the Table below.Poster Viewing Abstract 3370; TableMean DSC and MDA results for comparison of spheres in 3 anatomical regionsMean results for different DIR typesBase of brainstemPost of larynxFloor of mouthDSCMDA(SD) mmDSCMDA(SD) mmDSCMDA(SD) mmCompounded accuracy test1 observer for 5 patients (5 measurements)0.802.01(1.29)0.821.85(1.28)0.841.56(1.08)Inter-observer reproducibility for:pCT - iMR4 observers for 3 patients (18 measurements)0.980.21(0.22)0.970.25(0.24)0.980.19(0.21)pCT - MR4 observers for 3 patients (18 measurements)0.900.92(0.70)0.841.78(1.33)0.910.85(0.58)iMR - MR4 observers for 3 patients (18 measurements)0.891.05(0.80)0.950.48(0.41)0.950.47(0.41)Intra-observer reproducibility for pCT-iMR4 observers (at 3 times) for 3 patients (36 measurements)0.980.19(0.18)0.980.21(0.20)0.980.18(0.18) Open table in a new tab The compounded accuracy of contour propagation over all registration types for DIR was 1.5-2mm in all regions tested. This accuracy was similar to the sum of MDA due to inter-observer reproducibility over all 3 steps individually and hence is likely to be around the limit of the software tested given the resolution of images used. Inter-observer results show the pCT - iMR registration is the most reproducible, with minimal differences for the 3 regions tested. Intra-observer reproducibility was found to be high with DSC≥0.98 and MDA ∼0.2mm. This work suggests that acquiring iMR provides superior reproducibility for contour transformation using DIR." @default.
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• W2012117729 date "2012-11-01" @default.
• W2012117729 modified "2023-10-18" @default.
• W2012117729 title "Assessment of Accuracy and Reproducibility of Automatic Deformable Image Registration for Head and Neck Radiation Therapy" @default.
• W2012117729 doi "https://doi.org/10.1016/j.ijrobp.2012.07.1961" @default.
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