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- W2012118214 abstract "The complete replication cycle of influenza A virus was studied by means of the electron microscope in Ehrlich ascites tumor cells kept in vitro. Adsorption of virus in the cold followed by incubation at 36°C produced synchrony of early infection. Using high multiplicities of infection, specific phagocytosis of viral particles could be shown. Twenty-five to 90 min after penetration the virus disintegrated within phagocytic vesicles. Events during the eclipse phase could not be observed. Morphological changes in the nucleus 6 h after infection (at a time when budding of viral particles at the cellular periphery was already taking place) seemed to be phenomena of secondary nature. The budding process was studied by thin sectioning and freeze etching, which allowed a re-interpretation of the viral structure." @default.
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- W2012118214 date "1970-01-01" @default.
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- W2012118214 title "Elektronenmikroskopische Untersuchungen über den Infektionszyklus von Influenza A-Viren in Ehrlich-Aszites-Tumor-Zellen" @default.
- W2012118214 doi "https://doi.org/10.1159/000162427" @default.
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