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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012118641> ?p ?o ?g. }

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• W2012118641 abstract "We report the systematic rational design and synthesis of new monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Characterization of compounds in vitro (including 9i; ML101) led to the determination of key structural requirements for BIR2 binding affinity. Compounds 9h and 9j sensitized TRAIL-resistant breast cancer cells to apoptotic cell death, highlighting the value of these probe compounds as tools to investigate the biology of XIAP." @default.
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• W2012118641 date "2011-07-01" @default.
• W2012118641 modified "2023-09-24" @default.
• W2012118641 title "Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP" @default.
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• W2012118641 doi "https://doi.org/10.1016/j.bmcl.2011.05.049" @default.
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