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• W2012120883 abstract "Engagement of the antigen-specific receptor (TCR) of CD4+ T lymphocytes without a second (costimulatory) signal prevents the subsequent production of interleukin-2 (IL-2) by these cells. Because IL-2 is a key immunoregulatory lymphokine and is also produced by a subset of CD8+ T cells that are able to kill target cells, the effect of engaging the TCR of one such clone in the absence of costimulatory signals was examined. The capacity for TCR-dependent IL-2 production was lost, indicating comparable costimulator-dependent signaling requirements for IL-2 production in CD4+ and CD8+ T cells. However, TCR-mediated cytotoxicity was not impaired, implying that costimulation is required for only certain TCR-dependent effector functions." @default.
• W2012120883 created "2016-06-24" @default.
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• W2012120883 date "1991-03-08" @default.
• W2012120883 modified "2023-10-14" @default.
• W2012120883 title "Split Anergy in a CD8⁺T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production" @default.
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• W2012120883 doi "https://doi.org/10.1126/science.1900952" @default.
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