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• W2012121490 abstract "Using in vitro translation and cell transfection assays, we previously demonstrated that the Na + -K + -ATPase β 1 mRNA species containing its longest 3′-untranslated region (UTR) exhibited the lowest translational efficiency. Here, employing deletions and in vivo expression assays, using direct injection of plasmids into rat ventricular myocardium, we identified a 143-nt segment located in the distal 3′-UTR of β 1 mRNA that was associated with decreased luciferase expression; interestingly, this segment contains three AUUUA motifs. Using RNA-protein binding assays and UV cross-linking of cRNA with cytosolic proteins of rat heart, we identified an ∼38-kDa protein that specifically bound to the cRNA encoding the 143-nt segment of β 1 mRNA 3′-UTR. Mutation of three nucleotides located in the middle region of the 143-nt segment, which was predicted to greatly disrupt a putative stem-loop structure of the cRNA in this region, was associated with reduced binding of the mutated cRNA to the protein migrating at ∼38 kDa. The cRNA encoding a segment of cyclooxygenase-2 mRNA 3′-UTR containing six AUUUA sequences did not bind the protein migrating at ∼38 kDa and did not compete with the binding of the wild-type 143-nt β 1 cRNA to the protein. The above results suggest that the 143-nt segment in the distal segment of the 3′-UTR of β 1 mRNA may play an important role in the control of β 1 -subunit expression." @default.
• W2012121490 created "2016-06-24" @default.
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• W2012121490 date "2004-03-01" @default.
• W2012121490 modified "2023-09-26" @default.
• W2012121490 title "Control of Na⁺-K⁺-ATPase β₁-subunit expression: role of 3′-untranslated region" @default.
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• W2012121490 doi "https://doi.org/10.1152/ajpcell.00117.2003" @default.
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