FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012121757> ?p ?o ?g. }

• W2012121757 endingPage "8305" @default.
• W2012121757 startingPage "8300" @default.
• W2012121757 abstract "Analysis by acid polyacrylamide/urea gel electrophoresis of 14 individual mitochondrial tRNAs (mt-tRNAs) from human cells has revealed a variable decrease in mobility of the aminoacylated relative to the nonacylated form, with the degree of separation of the two forms not being correlated with the mass, polar character, or charge of the amino acid. Separation of the charged and uncharged species has been found to be independent of tRNA denaturation, being observed also in the absence of urea. In another approach, electrophoresis through a perpendicular denaturing gradient gel of several individual mt-tRNAs has shown a progressive unfolding of the tRNA with increasing denaturant concentration, which is consistent with an initial disruption of tertiary interactions, followed by the sequential melting of the four stems of the cloverleaf structure. A detailed analysis of the unfolding process of charged and uncharged tRNALys and tRNALeu(UUR) has revealed that the separation of the two forms of these tRNAs persisted throughout the almost entire range of denaturant concentrations used and was lost upon denaturation of the last helical domain(s), which most likely included the amino acid acceptor stem. These observations strongly suggest that the electrophoretic retardation of the charged species reflects an aminoacylation-induced conformational change of the 3'-end of these mt-tRNAs, with possible significant implications in connection with the known role of the acceptor end in tRNA interactions with the ribosomal peptidyl transferase center and the elongation factor Tu." @default.
• W2012121757 created "2016-06-24" @default.
• W2012121757 creator A5008918795 @default.
• W2012121757 creator A5061536209 @default.
• W2012121757 date "1996-08-06" @default.
• W2012121757 modified "2023-09-23" @default.
• W2012121757 title "Evidence for aminoacylation-induced conformational changes in human mitochondrial tRNAs." @default.
• W2012121757 cites W1459268005 @default.
• W2012121757 cites W1526101099 @default.
• W2012121757 cites W1527698555 @default.
• W2012121757 cites W1528770098 @default.
• W2012121757 cites W1801236538 @default.
• W2012121757 cites W1982261101 @default.
• W2012121757 cites W1987160917 @default.
• W2012121757 cites W1992481862 @default.
• W2012121757 cites W1999576932 @default.
• W2012121757 cites W2000064612 @default.
• W2012121757 cites W2000783431 @default.
• W2012121757 cites W2004361703 @default.
• W2012121757 cites W2008587764 @default.
• W2012121757 cites W2009963879 @default.
• W2012121757 cites W2016181787 @default.
• W2012121757 cites W2019449559 @default.
• W2012121757 cites W2020581018 @default.
• W2012121757 cites W2026033820 @default.
• W2012121757 cites W2029005684 @default.
• W2012121757 cites W2036934168 @default.
• W2012121757 cites W2037255974 @default.
• W2012121757 cites W2039351850 @default.
• W2012121757 cites W2040031423 @default.
• W2012121757 cites W2043779724 @default.
• W2012121757 cites W2044884944 @default.
• W2012121757 cites W2052378583 @default.
• W2012121757 cites W2060184801 @default.
• W2012121757 cites W2066180422 @default.
• W2012121757 cites W2067393357 @default.
• W2012121757 cites W2082589966 @default.
• W2012121757 cites W2085791091 @default.
• W2012121757 cites W2086806397 @default.
• W2012121757 cites W2093091879 @default.
• W2012121757 cites W2095157340 @default.
• W2012121757 cites W2100295787 @default.
• W2012121757 cites W2108361054 @default.
• W2012121757 cites W2109291482 @default.
• W2012121757 cites W2139305314 @default.
• W2012121757 cites W4254119740 @default.
• W2012121757 doi "https://doi.org/10.1073/pnas.93.16.8300" @default.
• W2012121757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38665" @default.
• W2012121757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8710865" @default.
• W2012121757 hasPublicationYear "1996" @default.
• W2012121757 type Work @default.
• W2012121757 sameAs 2012121757 @default.
• W2012121757 citedByCount "26" @default.
• W2012121757 countsByYear W20121217572012 @default.
• W2012121757 countsByYear W20121217572013 @default.
• W2012121757 countsByYear W20121217572014 @default.
• W2012121757 countsByYear W20121217572015 @default.
• W2012121757 countsByYear W20121217572017 @default.
• W2012121757 crossrefType "journal-article" @default.
• W2012121757 hasAuthorship W2012121757A5008918795 @default.
• W2012121757 hasAuthorship W2012121757A5061536209 @default.
• W2012121757 hasBestOaLocation W20121217571 @default.
• W2012121757 hasConcept C104317684 @default.
• W2012121757 hasConcept C116084860 @default.
• W2012121757 hasConcept C12554922 @default.
• W2012121757 hasConcept C13965031 @default.
• W2012121757 hasConcept C151238385 @default.
• W2012121757 hasConcept C153957851 @default.
• W2012121757 hasConcept C185592680 @default.
• W2012121757 hasConcept C2776923230 @default.
• W2012121757 hasConcept C40250595 @default.
• W2012121757 hasConcept C515207424 @default.
• W2012121757 hasConcept C55493867 @default.
• W2012121757 hasConcept C67705224 @default.
• W2012121757 hasConcept C71240020 @default.
• W2012121757 hasConcept C8010536 @default.
• W2012121757 hasConcept C86803240 @default.
• W2012121757 hasConceptScore W2012121757C104317684 @default.
• W2012121757 hasConceptScore W2012121757C116084860 @default.
• W2012121757 hasConceptScore W2012121757C12554922 @default.
• W2012121757 hasConceptScore W2012121757C13965031 @default.
• W2012121757 hasConceptScore W2012121757C151238385 @default.
• W2012121757 hasConceptScore W2012121757C153957851 @default.
• W2012121757 hasConceptScore W2012121757C185592680 @default.
• W2012121757 hasConceptScore W2012121757C2776923230 @default.
• W2012121757 hasConceptScore W2012121757C40250595 @default.
• W2012121757 hasConceptScore W2012121757C515207424 @default.
• W2012121757 hasConceptScore W2012121757C55493867 @default.
• W2012121757 hasConceptScore W2012121757C67705224 @default.
• W2012121757 hasConceptScore W2012121757C71240020 @default.
• W2012121757 hasConceptScore W2012121757C8010536 @default.
• W2012121757 hasConceptScore W2012121757C86803240 @default.
• W2012121757 hasIssue "16" @default.
• W2012121757 hasLocation W20121217571 @default.
• W2012121757 hasLocation W20121217572 @default.
• W2012121757 hasLocation W20121217573 @default.
• W2012121757 hasLocation W20121217574 @default.
• W2012121757 hasLocation W20121217575 @default.

• next