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• W2012121978 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Dec 2001FIBROBLAST GROWTH FACTOR-7 REGULATES STRATIFICATION OF THE BLADDER UROTHELIUM JENNIFER A. TASH, SCOTT G. DAVID, E.DARRACOTT VAUGHAN, and DORIS A. HERZLINGER JENNIFER A. TASHJENNIFER A. TASH More articles by this author , SCOTT G. DAVIDSCOTT G. DAVID More articles by this author , E.DARRACOTT VAUGHANE.DARRACOTT VAUGHAN More articles by this author , and DORIS A. HERZLINGERDORIS A. HERZLINGER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65630-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The cellular and molecular mechanisms that regulate the organization of bladder urothelium into basal, intermediate and superficial cell layers remain poorly understood. We tested the hypothesis that fibroblast growth factor (FGF)-7 is essential for generating a multilayered stratified bladder epithelium. Materials and Methods: The morphological and molecular characteristics of bladder urothelium in age and sex matched FGF-7 +/+ wild-type and −/− null mice were evaluated. In addition, the effect of exogenous FGF-7 on the growth and differentiation of primary murine urothelial cells was assessed. Results: Morphometric analyses demonstrate that FGF-7 null urothelium is markedly thinned compared with wild-type urothelium. Electron microscopy revealed that null urothelium lacks the intermediate cell layers and molecular marker analyses confirmed this observation. In vitro cell culture experiments indicated that FGF-7 regulates urothelial cell growth, differentiation and stratification. Primary urothelial cultures maintained without FGF-7 ceased to divide and expressed proteins characteristic of terminally differentiated umbrella cells. In contrast, cultures maintained with exogenous FGF-7 contained proliferating epithelial cells with protein expression patterns consistent with those of intermediate cells in addition to terminally differentiated, post-mitotic umbrella cells. Importantly, isolated urothelial cells maintained with exogenous FGF-7 formed a multilayered epithelium in vitro. Conclusions: Collectively these data indicate that FGF-7 is essential for normal bladder urothelial stratification, specifically the formation of the intermediate cell layers. Fibroblast growth factor-7 stimulates urothelial proliferation and delays the differentiation of these cells into post-mitotic umbrella cells. References 1 : Cell replacement and differentiation in transitional epithelium: a histological and autoradiographic study of the guinea-pig bladder and ureter. J Anat1972; 112: 433. Google Scholar 2 : Physiology and Pharmacology of the Bladder and Urethra. In: Campbell’s Urology. Edited by . Philadelphia: W. B. 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Google Scholar From the Department of Urology, James Buchanan Brady Urology Foundation, and Department of Physiology and Biophysics, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAtala A (2019) Re: Mouse and Human Urothelial Cancer Organoids: A Tool for Bladder Cancer ResearchJournal of Urology, VOL. 202, NO. 4, (664-664), Online publication date: 1-Oct-2019.Hauser P, Dozmorov M, Bane B, Slobodov G, Culkin D and Hurst R (2007) Abnormal Expression of Differentiation Related Proteins and Proteoglycan Core Proteins in the Urothelium of Patients With Interstitial CystitisJournal of Urology, VOL. 179, NO. 2, (764-769), Online publication date: 1-Feb-2008.MUDGE C and KLUMPP D (2018) INDUCTION OF THE UROTHELIAL DIFFERENTIATION PROGRAM IN THE ABSENCE OF STROMAL CUESJournal of Urology, VOL. 174, NO. 1, (380-385), Online publication date: 1-Jul-2005.MUNRO N and KNOWLES M (2018) Fibroblast Growth Factors and Their Receptors in Transitional Cell CarcinomaJournal of Urology, VOL. 169, NO. 2, (675-682), Online publication date: 1-Feb-2003. Volume 166Issue 6December 2001Page: 2536-2541 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsfibroblast growth factorepitheliumurotheliumbladdercell differentiationMetricsAuthor Information JENNIFER A. TASH More articles by this author SCOTT G. DAVID More articles by this author E.DARRACOTT VAUGHAN More articles by this author DORIS A. HERZLINGER More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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