FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012123457> ?p ?o ?g. }

• W2012123457 endingPage "83" @default.
• W2012123457 startingPage "71" @default.
• W2012123457 abstract "Patients with temporal lobe epilepsy are frequently afflicted with psychiatric comorbidity and deficits in spatial and other forms of declarative memory. The relationship between epilepsy and psychopathology is poorly understood, so that systematic research in this area is important. In the present study, we characterized various behaviors and learning and memory in a mouse model in which major aspects of mesial temporal lobe epilepsy can be reproduced. In this model, a single unilateral injection of kainate into the dorsal hippocampus induces a nonconvulsive status epilepticus, followed by development of spontaneous recurrent seizures and ipsilateral lesions of CA1, CA3c and dentate hilus neurons. Unexpectedly, the epileptic mice exhibited only few alterations in a behavioral test battery used to investigate locomotor activity and function, emotionality, depression-related behavior and learning and memory. In contrast to recent experiments with the same test battery in epileptic mice generated by systemic administration of pilocarpine, mice with focal kainate administration did not exhibit reduced explorative behavior or increases of anxiety-related behavior. However, similar to pilocarpine-treated mice, a decrease in depression-like behavior was observed in the forced swimming test. In the Morris water maze test, kainate-treated animals exhibited retarded acquisition and impaired retention of visual-spatial information. Our data suggest that the focal kainate model of mesial temporal lobe epilepsy may contribute to understanding the neurobiological mechanisms underlying the association between epilepsy and behavioral or cognitive alterations." @default.
• W2012123457 created "2016-06-24" @default.
• W2012123457 creator A5004040780 @default.
• W2012123457 creator A5010235451 @default.
• W2012123457 creator A5023942525 @default.
• W2012123457 date "2008-09-01" @default.
• W2012123457 modified "2023-09-25" @default.
• W2012123457 title "Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate" @default.
• W2012123457 cites W125809592 @default.
• W2012123457 cites W1568472238 @default.
• W2012123457 cites W1964522892 @default.
• W2012123457 cites W1964600153 @default.
• W2012123457 cites W1966037459 @default.
• W2012123457 cites W1966940145 @default.
• W2012123457 cites W1967061503 @default.
• W2012123457 cites W1975357199 @default.
• W2012123457 cites W1976973106 @default.
• W2012123457 cites W1977013974 @default.
• W2012123457 cites W1980175371 @default.
• W2012123457 cites W1981018013 @default.
• W2012123457 cites W1984025514 @default.
• W2012123457 cites W1984476861 @default.
• W2012123457 cites W1984713681 @default.
• W2012123457 cites W1988904564 @default.
• W2012123457 cites W1993220836 @default.
• W2012123457 cites W1994781509 @default.
• W2012123457 cites W1996166611 @default.
• W2012123457 cites W2000289247 @default.
• W2012123457 cites W2005648670 @default.
• W2012123457 cites W2008201111 @default.
• W2012123457 cites W2013082402 @default.
• W2012123457 cites W2018021139 @default.
• W2012123457 cites W2020184819 @default.
• W2012123457 cites W2023292449 @default.
• W2012123457 cites W2027571586 @default.
• W2012123457 cites W2031880368 @default.
• W2012123457 cites W2032290775 @default.
• W2012123457 cites W2033730973 @default.
• W2012123457 cites W2034474299 @default.
• W2012123457 cites W2034952028 @default.
• W2012123457 cites W2037111632 @default.
• W2012123457 cites W2044682977 @default.
• W2012123457 cites W2045932599 @default.
• W2012123457 cites W2049695554 @default.
• W2012123457 cites W2053130025 @default.
• W2012123457 cites W2060969086 @default.
• W2012123457 cites W2068879317 @default.
• W2012123457 cites W2068910138 @default.
• W2012123457 cites W2081752203 @default.
• W2012123457 cites W2082871906 @default.
• W2012123457 cites W2087977249 @default.
• W2012123457 cites W2088188719 @default.
• W2012123457 cites W2103946141 @default.
• W2012123457 cites W2114775672 @default.
• W2012123457 cites W2123843070 @default.
• W2012123457 cites W2127379279 @default.
• W2012123457 cites W2145016695 @default.
• W2012123457 cites W2162771038 @default.
• W2012123457 cites W2162807213 @default.
• W2012123457 cites W2165492811 @default.
• W2012123457 cites W2169473035 @default.
• W2012123457 doi "https://doi.org/10.1016/j.expneurol.2008.04.036" @default.
• W2012123457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18585709" @default.
• W2012123457 hasPublicationYear "2008" @default.
• W2012123457 type Work @default.
• W2012123457 sameAs 2012123457 @default.
• W2012123457 citedByCount "132" @default.
• W2012123457 countsByYear W20121234572012 @default.
• W2012123457 countsByYear W20121234572013 @default.
• W2012123457 countsByYear W20121234572014 @default.
• W2012123457 countsByYear W20121234572015 @default.
• W2012123457 countsByYear W20121234572016 @default.
• W2012123457 countsByYear W20121234572017 @default.
• W2012123457 countsByYear W20121234572018 @default.
• W2012123457 countsByYear W20121234572019 @default.
• W2012123457 countsByYear W20121234572020 @default.
• W2012123457 countsByYear W20121234572021 @default.
• W2012123457 countsByYear W20121234572022 @default.
• W2012123457 countsByYear W20121234572023 @default.
• W2012123457 crossrefType "journal-article" @default.
• W2012123457 hasAuthorship W2012123457A5004040780 @default.
• W2012123457 hasAuthorship W2012123457A5010235451 @default.
• W2012123457 hasAuthorship W2012123457A5023942525 @default.
• W2012123457 hasConcept C118552586 @default.
• W2012123457 hasConcept C12515866 @default.
• W2012123457 hasConcept C126322002 @default.
• W2012123457 hasConcept C136569192 @default.
• W2012123457 hasConcept C15744967 @default.
• W2012123457 hasConcept C160268369 @default.
• W2012123457 hasConcept C169760540 @default.
• W2012123457 hasConcept C170493617 @default.
• W2012123457 hasConcept C173586616 @default.
• W2012123457 hasConcept C189184402 @default.
• W2012123457 hasConcept C2777341932 @default.
• W2012123457 hasConcept C2778186239 @default.
• W2012123457 hasConcept C2779177272 @default.
• W2012123457 hasConcept C2781099131 @default.
• W2012123457 hasConcept C2781161787 @default.

• next