Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012123586> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2012123586 endingPage "30" @default.
- W2012123586 startingPage "25" @default.
- W2012123586 abstract "Methylene dianiline (DDM) causes a dose- and time-dependent cholestasis, bile ductular epithelial injury, and hepatic parenchymal insult in rats. The mechanism of toxicity is unknown. Since hepatic leukocyte infiltration is a prominent feature of DDM-induced liver injury, and because leukocytes play a causal role in hepatic and extrahepatic tissue injury, we tested the hypothesis that toxicity caused by DDM is dependent on neutrophils or other circulating inflammatory cells. A polyclonal antibody (NAb) against rat neutrophils was used to address the role of the neutrophil in DDM-induced liver injury. NAb administration caused a significant reduction in circulating neutrophils without altering other leukocyte numbers. Moreover, NAb pretreatment prevented hepatic neutrophil infiltration after administration of DDM. However, neutrophil depletion did not afford protection from DDM-induced liver injury. This result was confirmed and the role of other circulating leukocytes was evaluated by inducing systemic leukopenia using cyclophosphamide (CYCLO). Administration of CYCLO diminished the number of circulating leukocytes within 4 days after treatment. Depletion of leukocytes by CYCLO prevented the hepatic accumulation of leukocytes but did not protect rats from DDM hepatotoxicity. These results suggest that the large numbers of leukocytes that infiltrate the liver after DDM administration do not contribute to hepatic injury." @default.
- W2012123586 created "2016-06-24" @default.
- W2012123586 creator A5026002747 @default.
- W2012123586 creator A5026842829 @default.
- W2012123586 creator A5028376473 @default.
- W2012123586 creator A5068840488 @default.
- W2012123586 date "1994-01-01" @default.
- W2012123586 modified "2023-09-27" @default.
- W2012123586 title "Methylene Dianiline Hepatotoxicity Is Not Leukocyte-Dependent" @default.
- W2012123586 doi "https://doi.org/10.1006/taap.1994.1004" @default.
- W2012123586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8291058" @default.
- W2012123586 hasPublicationYear "1994" @default.
- W2012123586 type Work @default.
- W2012123586 sameAs 2012123586 @default.
- W2012123586 citedByCount "7" @default.
- W2012123586 countsByYear W20121235862023 @default.
- W2012123586 crossrefType "journal-article" @default.
- W2012123586 hasAuthorship W2012123586A5026002747 @default.
- W2012123586 hasAuthorship W2012123586A5026842829 @default.
- W2012123586 hasAuthorship W2012123586A5028376473 @default.
- W2012123586 hasAuthorship W2012123586A5068840488 @default.
- W2012123586 hasConcept C121332964 @default.
- W2012123586 hasConcept C126322002 @default.
- W2012123586 hasConcept C153400128 @default.
- W2012123586 hasConcept C203014093 @default.
- W2012123586 hasConcept C203565725 @default.
- W2012123586 hasConcept C2776637226 @default.
- W2012123586 hasConcept C2776914184 @default.
- W2012123586 hasConcept C2778593092 @default.
- W2012123586 hasConcept C2780873365 @default.
- W2012123586 hasConcept C29730261 @default.
- W2012123586 hasConcept C71924100 @default.
- W2012123586 hasConcept C86803240 @default.
- W2012123586 hasConcept C97355855 @default.
- W2012123586 hasConcept C98274493 @default.
- W2012123586 hasConceptScore W2012123586C121332964 @default.
- W2012123586 hasConceptScore W2012123586C126322002 @default.
- W2012123586 hasConceptScore W2012123586C153400128 @default.
- W2012123586 hasConceptScore W2012123586C203014093 @default.
- W2012123586 hasConceptScore W2012123586C203565725 @default.
- W2012123586 hasConceptScore W2012123586C2776637226 @default.
- W2012123586 hasConceptScore W2012123586C2776914184 @default.
- W2012123586 hasConceptScore W2012123586C2778593092 @default.
- W2012123586 hasConceptScore W2012123586C2780873365 @default.
- W2012123586 hasConceptScore W2012123586C29730261 @default.
- W2012123586 hasConceptScore W2012123586C71924100 @default.
- W2012123586 hasConceptScore W2012123586C86803240 @default.
- W2012123586 hasConceptScore W2012123586C97355855 @default.
- W2012123586 hasConceptScore W2012123586C98274493 @default.
- W2012123586 hasIssue "1" @default.
- W2012123586 hasLocation W20121235861 @default.
- W2012123586 hasLocation W20121235862 @default.
- W2012123586 hasOpenAccess W2012123586 @default.
- W2012123586 hasPrimaryLocation W20121235861 @default.
- W2012123586 hasRelatedWork W1963617522 @default.
- W2012123586 hasRelatedWork W1981351515 @default.
- W2012123586 hasRelatedWork W2012123586 @default.
- W2012123586 hasRelatedWork W2087794733 @default.
- W2012123586 hasRelatedWork W2092593350 @default.
- W2012123586 hasRelatedWork W2167345155 @default.
- W2012123586 hasRelatedWork W2549229677 @default.
- W2012123586 hasRelatedWork W3176506233 @default.
- W2012123586 hasRelatedWork W4285405647 @default.
- W2012123586 hasRelatedWork W2739649644 @default.
- W2012123586 hasVolume "124" @default.
- W2012123586 isParatext "false" @default.
- W2012123586 isRetracted "false" @default.
- W2012123586 magId "2012123586" @default.
- W2012123586 workType "article" @default.