FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012123837> ?p ?o ?g. }

• W2012123837 endingPage "594" @default.
• W2012123837 startingPage "583" @default.
• W2012123837 abstract "We and others have recently obtained data suggesting that cytokine-STAT signaling in many different cell-types is a chaperoned pathway initiated at the level of specialized plasma membrane microdomains called rafts (the raft-STAT signaling hypothesis). These findings are of broad significance in that all cytokines and growth factors initiate signaling in target cells by interacting with respective cell-surface receptors. The new data suggest that raft microdomains represent the units of function at the cell-surface through which ligand-stimulated STAT signaling is initiated. Moreover, recent evidence shows the involvement of chaperone proteins in regulating the STAT signaling pathway. These chaperones include the human homolog of the tumorous imaginal disc 1 protein (hTid1) which associates with Janus kinase 2 (JAK2) at the level of the plasma membrane, heat shock protein 90 (HSP90) which associates with STAT3 and STAT1 proteins in caveolin-1-containing raft and cytoplasmic complexes, and glucose regulated protein 58 (GRP58/ER-60/ERp57), a thiol dependent protein-disulfide isomerase, found in association with STAT3 statosome complexes in the cytosol and in the raft fraction. We suggest a function of the HSP90 chaperone system in preserving IL-6/STAT3 signaling in liver cells in the context of fever. The identification and function of protein partners associated with specific STAT species in rafts and in cytosolic complexes, and in the efficient departure of cytokine-activated STATs from the cytosolic face of rafts towards the cell nucleus are now areas of active investigation." @default.
• W2012123837 created "2016-06-24" @default.
• W2012123837 creator A5064719174 @default.
• W2012123837 date "2003-09-30" @default.
• W2012123837 modified "2023-09-25" @default.
• W2012123837 title "Plasma membrane rafts and chaperones in cytokine/STAT signaling." @default.
• W2012123837 cites W108420520 @default.
• W2012123837 cites W14462992 @default.
• W2012123837 cites W1483668469 @default.
• W2012123837 cites W1517168785 @default.
• W2012123837 cites W1520284993 @default.
• W2012123837 cites W1564861448 @default.
• W2012123837 cites W1963827194 @default.
• W2012123837 cites W1971935872 @default.
• W2012123837 cites W1978795424 @default.
• W2012123837 cites W1987270140 @default.
• W2012123837 cites W1994810882 @default.
• W2012123837 cites W1996479930 @default.
• W2012123837 cites W2006852109 @default.
• W2012123837 cites W2012389696 @default.
• W2012123837 cites W2014154667 @default.
• W2012123837 cites W2014211869 @default.
• W2012123837 cites W2025646685 @default.
• W2012123837 cites W2026621967 @default.
• W2012123837 cites W2027345997 @default.
• W2012123837 cites W2036452124 @default.
• W2012123837 cites W2044002279 @default.
• W2012123837 cites W2061306848 @default.
• W2012123837 cites W2067308415 @default.
• W2012123837 cites W2068800887 @default.
• W2012123837 cites W2069444054 @default.
• W2012123837 cites W2072532644 @default.
• W2012123837 cites W2074721095 @default.
• W2012123837 cites W2079522334 @default.
• W2012123837 cites W2086715846 @default.
• W2012123837 cites W2088929311 @default.
• W2012123837 cites W2091638984 @default.
• W2012123837 cites W2092437783 @default.
• W2012123837 cites W2094933885 @default.
• W2012123837 cites W2094989950 @default.
• W2012123837 cites W2095480781 @default.
• W2012123837 cites W2100671598 @default.
• W2012123837 cites W2121858640 @default.
• W2012123837 cites W2130421133 @default.
• W2012123837 cites W2135697324 @default.
• W2012123837 cites W2135709160 @default.
• W2012123837 cites W2151909183 @default.
• W2012123837 cites W2156681554 @default.
• W2012123837 cites W2166298672 @default.
• W2012123837 cites W2246568657 @default.
• W2012123837 cites W2411386336 @default.
• W2012123837 cites W2995395594 @default.
• W2012123837 cites W581289259 @default.
• W2012123837 cites W596682545 @default.
• W2012123837 cites W605023124 @default.
• W2012123837 cites W650603698 @default.
• W2012123837 cites W78779654 @default.
• W2012123837 cites W89734555 @default.
• W2012123837 doi "https://doi.org/10.18388/abp.2003_3652" @default.
• W2012123837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14515141" @default.
• W2012123837 hasPublicationYear "2003" @default.
• W2012123837 type Work @default.
• W2012123837 sameAs 2012123837 @default.
• W2012123837 citedByCount "56" @default.
• W2012123837 countsByYear W20121238372012 @default.
• W2012123837 countsByYear W20121238372013 @default.
• W2012123837 countsByYear W20121238372014 @default.
• W2012123837 countsByYear W20121238372015 @default.
• W2012123837 countsByYear W20121238372016 @default.
• W2012123837 countsByYear W20121238372018 @default.
• W2012123837 countsByYear W20121238372019 @default.
• W2012123837 countsByYear W20121238372021 @default.
• W2012123837 crossrefType "journal-article" @default.
• W2012123837 hasAuthorship W2012123837A5064719174 @default.
• W2012123837 hasBestOaLocation W20121238371 @default.
• W2012123837 hasConcept C104317684 @default.
• W2012123837 hasConcept C142724271 @default.
• W2012123837 hasConcept C15920480 @default.
• W2012123837 hasConcept C178790620 @default.
• W2012123837 hasConcept C181199279 @default.
• W2012123837 hasConcept C185592680 @default.
• W2012123837 hasConcept C205260736 @default.
• W2012123837 hasConcept C2775932338 @default.
• W2012123837 hasConcept C2775962898 @default.
• W2012123837 hasConcept C51785407 @default.
• W2012123837 hasConcept C521977710 @default.
• W2012123837 hasConcept C55493867 @default.
• W2012123837 hasConcept C62478195 @default.
• W2012123837 hasConcept C71924100 @default.
• W2012123837 hasConcept C79266657 @default.
• W2012123837 hasConcept C86803240 @default.
• W2012123837 hasConcept C9132879 @default.
• W2012123837 hasConcept C95444343 @default.
• W2012123837 hasConcept C98539663 @default.
• W2012123837 hasConceptScore W2012123837C104317684 @default.
• W2012123837 hasConceptScore W2012123837C142724271 @default.
• W2012123837 hasConceptScore W2012123837C15920480 @default.
• W2012123837 hasConceptScore W2012123837C178790620 @default.

• next