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- W2012124023 abstract "Nitric oxide (NO), a highly versatile signaling molecule, exerts a broad range of regulatory influences in the cardiovascular system that extends from vasodilation to myocardial contractility, angiogenesis, inflammation, and energy metabolism. Considerable attention has been paid to deciphering the mechanisms for such diversity in signaling. S-nitrosylation of cysteine thiols is a major signaling pathway through which NO exerts its actions. An emerging concept of NO pathophysiology is that the interplay between NO and reactive oxygen species (ROS), the nitroso/redox balance, is an important regulator of cardiovascular homeostasis. ROS react with NO, limit its bioavailability, and compete with NO for binding to the same thiol in effector molecules. The interplay between NO and ROS appears to be tightly regulated and spatially confined based on the co-localization of specific NO synthase (NOS) isoforms and oxidative enzymes in unique subcellular compartments. NOS isoforms are also in close contact with denitrosylases, leading to crucial regulation of S-nitrosylation. Nitroso/redox balance is an emerging regulatory pathway for multiple cells and tissues, including the cardiovascular system. Studies using relevant knockout models, isoform specific NOS inhibitors, and both in vitro and in vivo methods have provided novel insights into NO- and ROS-based signaling interactions responsible for numerous cardiovascular disorders. An integrated view of the role of nitroso/redox balance in cardiovascular pathophysiology has significant therapeutic implications. This is highlighted by human studies where pharmacologic manipulation of oxidative and nitrosative pathways exerted salutary effects in patients with advanced heart failure. This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation." @default.
- W2012124023 created "2016-06-24" @default.
- W2012124023 creator A5058008648 @default.
- W2012124023 creator A5085774808 @default.
- W2012124023 date "2012-06-01" @default.
- W2012124023 modified "2023-10-02" @default.
- W2012124023 title "Regulation of cardiovascular cellular processes by S-nitrosylation" @default.
- W2012124023 cites W1414418298 @default.
- W2012124023 cites W1481638738 @default.
- W2012124023 cites W1488493608 @default.
- W2012124023 cites W1577861060 @default.
- W2012124023 cites W1607892649 @default.
- W2012124023 cites W1678800844 @default.
- W2012124023 cites W1828441724 @default.
- W2012124023 cites W1854632454 @default.
- W2012124023 cites W1897522638 @default.
- W2012124023 cites W1953423403 @default.
- W2012124023 cites W1963543097 @default.
- W2012124023 cites W1964526269 @default.
- W2012124023 cites W1968348700 @default.
- W2012124023 cites W1969054288 @default.
- W2012124023 cites W1969916539 @default.
- W2012124023 cites W1969968096 @default.
- W2012124023 cites W1970498090 @default.
- W2012124023 cites W1973003784 @default.
- W2012124023 cites W1975228087 @default.
- W2012124023 cites W1976851726 @default.
- W2012124023 cites W1977190827 @default.
- W2012124023 cites W1977394169 @default.
- W2012124023 cites W1977778531 @default.
- W2012124023 cites W1983871510 @default.
- W2012124023 cites W1984018231 @default.
- W2012124023 cites W1987213472 @default.
- W2012124023 cites W1988734169 @default.
- W2012124023 cites W1989695520 @default.
- W2012124023 cites W1990172377 @default.
- W2012124023 cites W1990215202 @default.
- W2012124023 cites W1990738801 @default.
- W2012124023 cites W1992254322 @default.
- W2012124023 cites W1992385339 @default.
- W2012124023 cites W1993854825 @default.
- W2012124023 cites W1995896668 @default.
- W2012124023 cites W1998391272 @default.
- W2012124023 cites W1998905001 @default.
- W2012124023 cites W2000806054 @default.
- W2012124023 cites W2001386863 @default.
- W2012124023 cites W2001461795 @default.
- W2012124023 cites W2003091555 @default.
- W2012124023 cites W2003344121 @default.
- W2012124023 cites W2003379664 @default.
- W2012124023 cites W2004724154 @default.
- W2012124023 cites W2005591501 @default.
- W2012124023 cites W2005678263 @default.
- W2012124023 cites W2006641024 @default.
- W2012124023 cites W2006659891 @default.
- W2012124023 cites W2006668050 @default.
- W2012124023 cites W2007415167 @default.
- W2012124023 cites W2009117933 @default.
- W2012124023 cites W2009601307 @default.
- W2012124023 cites W2013818100 @default.
- W2012124023 cites W2015379716 @default.
- W2012124023 cites W2019738475 @default.
- W2012124023 cites W2021159562 @default.
- W2012124023 cites W2022008878 @default.
- W2012124023 cites W2022595505 @default.
- W2012124023 cites W2023423937 @default.
- W2012124023 cites W2023943529 @default.
- W2012124023 cites W2025971186 @default.
- W2012124023 cites W2026728447 @default.
- W2012124023 cites W2029491963 @default.
- W2012124023 cites W2031681500 @default.
- W2012124023 cites W2033357754 @default.
- W2012124023 cites W2033767220 @default.
- W2012124023 cites W2033895351 @default.
- W2012124023 cites W2034946903 @default.
- W2012124023 cites W2035423155 @default.
- W2012124023 cites W2037755911 @default.
- W2012124023 cites W2038545399 @default.
- W2012124023 cites W2040603631 @default.
- W2012124023 cites W2040852689 @default.
- W2012124023 cites W2041034845 @default.
- W2012124023 cites W2044438496 @default.
- W2012124023 cites W2045408001 @default.
- W2012124023 cites W2046230753 @default.
- W2012124023 cites W2046795038 @default.
- W2012124023 cites W2050769426 @default.
- W2012124023 cites W2051209160 @default.
- W2012124023 cites W2052931335 @default.
- W2012124023 cites W2054027791 @default.
- W2012124023 cites W2054875792 @default.
- W2012124023 cites W2056880825 @default.
- W2012124023 cites W2058520514 @default.
- W2012124023 cites W2062541458 @default.
- W2012124023 cites W2063302293 @default.
- W2012124023 cites W2064122322 @default.
- W2012124023 cites W2065201989 @default.
- W2012124023 cites W2065773243 @default.
- W2012124023 cites W2067575053 @default.