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- W2012125436 abstract "Parece que un eslabón en la patogenia de la hemocromatosis hereditaria tipo 1 es la sobreexpresión de un transportador de cationes divalentes duodenal (DMT1) causante de la absorción del hierro2+ no hemínico. El objetivo del presente estudio ha sido valorar si el bloqueo competitivo de DMT1 mediante la administración de dosis altas de magnesio2+ por vía oral reduce la absorción de hierro en pacientes homocigotos para la mutación C282Y. Mediante un ensayo clínico cruzado se investigó la absorción de hierro mediante el test de absorción de bajas dosis de hierro en un grupo de 15 pacientes antes y después de ingerir durante 2 semanas una dosis de magnesio de 809,6 mg cada 8 h. No se observaron efectos secundarios ni diferencias estadísticamente significativas entre la absorción de hierro antes y después del tratamiento experimental (14,7 μmol/l, intervalo de confianza [IC] del 95%, 9,8-19,6, frente a 14,9 μmol/l, IC del 95%, 8,5-21,4; p = 0,7). El tratamiento con magnesio oral no reduce la absorción de hierro en los pacientes homocigotos C282Y. Dicho tratamiento no puede ser una alternativa terapéutica a las flebotomías. An essential step in the pathogenesis of hereditary hemochromatosis seems to be the increased expression of a duodenal divalent cation transporter (DMT1) responsible for absorption of non-heminic iron2+. The objective of the present study was to ascertain whether the competitive blockade of DMT1 by the administration of high doses of oral Mg2+ reduces iron absorption in patients homozygous for the C282Y mutation. Iron absorption was evaluated by a low dose iron absorption test in 15 patients before and after treatment with oral magnesium (809.6 mg every 8 hours) for two weeks. We did not observe secondary effects or significant differences in iron absorption before or after magnesium treatment (14.7 μmol/L; 95% confidence interval [CI], 9.8-19.6 vs 14.9 μmol/L; 95% CI, 8.5-21.4, P = 0.7). Treatment with oral magnesium does not reduce iron absorption in homozygous C282Y patients. This treatment can not be used in these subjects." @default.
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- W2012125436 date "2006-04-01" @default.
- W2012125436 modified "2023-10-17" @default.
- W2012125436 title "Tratamiento de la hemocromatosis hereditaria tipo 1 con magnesio oral" @default.
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- W2012125436 doi "https://doi.org/10.1157/13087717" @default.
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