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• W2012125630 abstract "Thymic selection of the developing T cell repertoire is thought to occur at the CD4+CD8+ stage of differentiation and to be determined by the specificity of the T cell receptors (TCRs) that CD4+CD8+ thymocytes express. However, TCR signals can inhibit the differentiation of precursor thymocytes into CD4+CD8+ cells, which suggests that selection might occur earlier than thought. Indeed, in a negatively selecting male thymus, CD4-CD8lo precursor thymocytes that express a transgenic TCR to male antigen are developmentally arrested as a consequence of antigen encounter and fail to become CD4+CD8+. Thus, negative selection can occur before the CD4+CD8+ stage of differentiation." @default.
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• W2012125630 date "1992-10-23" @default.
• W2012125630 modified "2023-10-16" @default.
• W2012125630 title "Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells" @default.
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• W2012125630 doi "https://doi.org/10.1126/science.1357752" @default.
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