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• W2012126538 abstract "Hydroxyl radical is one of the major reactive oxygen species (ROS) formed from gamma-radiolysis of water or Fenton reaction, and it can abstract one hydrogen atom from the methyl carbon atom of thymine and 5-methylcytosine to give the 5-methyl radical of the pyrimidine bases. The latter radical can also be induced from Type-I photo-oxidation process. Here, we examined the reactivity of the independently generated 5-(2'-deoxycytidyl)methyl radical (I) in single- and double-stranded oligodeoxyribonucleotides (ODNs). It was found that an intrastrand cross-link lesion, in which the methyl carbon atom of 5-methylcytosine and the C8 carbon atom of guanine are covalently bonded, could be formed from the independently generated radical at both GmC and mCG sites, with the yield being much higher at the former site. We also showed by LC-MS/MS that the same cross-link lesions were formed in mC-containing duplex ODNs upon gamma irradiation under both aerobic and anaerobic conditions, and the yield was approximately 10-fold higher under the latter conditions. The independently generated radical allows for the availability of pure, sufficient and well-characterized intrastrand cross-link lesion-bearing ODN substrates for future biochemical and biophysical characterizations. This was also the first demonstration that the coupling of radical I with its 5' neighboring guanine can occur in the presence of molecular oxygen, suggesting that the formation of this and other types of intrastrand cross-link lesions might have important implications in the cytotoxic effects of ROS." @default.
• W2012126538 created "2016-06-24" @default.
• W2012126538 creator A5025279909 @default.
• W2012126538 creator A5039723064 @default.
• W2012126538 date "2005-03-08" @default.
• W2012126538 modified "2023-10-18" @default.
• W2012126538 title "Generation of 5-(2'-deoxycytidyl)methyl radical and the formation of intrastrand cross-link lesions in oligodeoxyribonucleotides" @default.
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• W2012126538 doi "https://doi.org/10.1093/nar/gki301" @default.
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