FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012127536> ?p ?o ?g. }

• W2012127536 endingPage "1664" @default.
• W2012127536 startingPage "1651" @default.
• W2012127536 abstract "Imatinib mesylate suppresses phosphorylation of its kinase target, Bcr-Abl. We hypothesized that loss of p210Bcr-Abl (the kinase target) may lead to imatinib mesylate resistance. We studied K562 cells [chronic myelogenous leukemia (CML) blast crisis line] and MO7E/MBA-1 cells (with MBA-1 cells representing MO7E cells stably transfected with BCR-ABL). Imatinib mesylate resistance developed when p210Bcr-Abl expression was abolished. Furthermore, K562 cells were significantly more growth suppressed after imatinib mesylate exposure than after downregulation of Bcr-Abl expression. Signaling pathways which were functional in the absence of Bcr-Abl expression (NF-kappaB and mitogen-activated protein kinase activation or the growth factor pathway) were disrupted when p210Bcr-Abl was present but dephosphorylated, suggesting that an intact, but enzymatically inactive Bcr-Abl, may interfere with critical growth/signaling pathways. Downregulation of p210Bcr-Abl may be a mechanism by which imatinib mesylate resistance emerges. Samples from three of 15 patients with imatinib mesylate-resistant CML blast crisis had undetectable levels of p210Bcr-Abl. We conclude that retention of a dephosphorylated p210Bcr-Abl has a biologic impact distinct from that of downregulation/loss of p210Bcr-Abl and, in a subset of patients, loss of the target of the kinase inhibitor may lead to imatinib mesylate resistance." @default.
• W2012127536 created "2016-06-24" @default.
• W2012127536 creator A5011529063 @default.
• W2012127536 creator A5034182089 @default.
• W2012127536 creator A5053481267 @default.
• W2012127536 creator A5084290698 @default.
• W2012127536 date "2006-01-01" @default.
• W2012127536 modified "2023-09-23" @default.
• W2012127536 title "Distinct biological impact of dephosphorylation vs. downregulation of p210Bcr-Abl: Implications for imatinib mesylate response and resistance" @default.
• W2012127536 cites W120419820 @default.
• W2012127536 cites W1490418776 @default.
• W2012127536 cites W1501358984 @default.
• W2012127536 cites W1965295262 @default.
• W2012127536 cites W1999614615 @default.
• W2012127536 cites W2000799155 @default.
• W2012127536 cites W2015616444 @default.
• W2012127536 cites W2016086822 @default.
• W2012127536 cites W2025206980 @default.
• W2012127536 cites W2025564151 @default.
• W2012127536 cites W2039925656 @default.
• W2012127536 cites W2069093904 @default.
• W2012127536 cites W2074740152 @default.
• W2012127536 cites W2077047827 @default.
• W2012127536 cites W2078336183 @default.
• W2012127536 cites W2097822594 @default.
• W2012127536 cites W2107015590 @default.
• W2012127536 cites W2113703021 @default.
• W2012127536 cites W2142969636 @default.
• W2012127536 cites W2166490712 @default.
• W2012127536 cites W2170875710 @default.
• W2012127536 cites W2261096875 @default.
• W2012127536 cites W2263837564 @default.
• W2012127536 cites W2312804644 @default.
• W2012127536 cites W2329648702 @default.
• W2012127536 doi "https://doi.org/10.1080/10428190600709572" @default.
• W2012127536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16966279" @default.
• W2012127536 hasPublicationYear "2006" @default.
• W2012127536 type Work @default.
• W2012127536 sameAs 2012127536 @default.
• W2012127536 citedByCount "2" @default.
• W2012127536 countsByYear W20121275362013 @default.
• W2012127536 crossrefType "journal-article" @default.
• W2012127536 hasAuthorship W2012127536A5011529063 @default.
• W2012127536 hasAuthorship W2012127536A5034182089 @default.
• W2012127536 hasAuthorship W2012127536A5053481267 @default.
• W2012127536 hasAuthorship W2012127536A5084290698 @default.
• W2012127536 hasConcept C104317684 @default.
• W2012127536 hasConcept C125418893 @default.
• W2012127536 hasConcept C127561419 @default.
• W2012127536 hasConcept C138626823 @default.
• W2012127536 hasConcept C171122931 @default.
• W2012127536 hasConcept C184235292 @default.
• W2012127536 hasConcept C203014093 @default.
• W2012127536 hasConcept C2776960273 @default.
• W2012127536 hasConcept C2777583451 @default.
• W2012127536 hasConcept C2778461978 @default.
• W2012127536 hasConcept C2778729363 @default.
• W2012127536 hasConcept C2778904597 @default.
• W2012127536 hasConcept C3019892230 @default.
• W2012127536 hasConcept C42362537 @default.
• W2012127536 hasConcept C502942594 @default.
• W2012127536 hasConcept C55493867 @default.
• W2012127536 hasConcept C62478195 @default.
• W2012127536 hasConcept C86803240 @default.
• W2012127536 hasConcept C95444343 @default.
• W2012127536 hasConceptScore W2012127536C104317684 @default.
• W2012127536 hasConceptScore W2012127536C125418893 @default.
• W2012127536 hasConceptScore W2012127536C127561419 @default.
• W2012127536 hasConceptScore W2012127536C138626823 @default.
• W2012127536 hasConceptScore W2012127536C171122931 @default.
• W2012127536 hasConceptScore W2012127536C184235292 @default.
• W2012127536 hasConceptScore W2012127536C203014093 @default.
• W2012127536 hasConceptScore W2012127536C2776960273 @default.
• W2012127536 hasConceptScore W2012127536C2777583451 @default.
• W2012127536 hasConceptScore W2012127536C2778461978 @default.
• W2012127536 hasConceptScore W2012127536C2778729363 @default.
• W2012127536 hasConceptScore W2012127536C2778904597 @default.
• W2012127536 hasConceptScore W2012127536C3019892230 @default.
• W2012127536 hasConceptScore W2012127536C42362537 @default.
• W2012127536 hasConceptScore W2012127536C502942594 @default.
• W2012127536 hasConceptScore W2012127536C55493867 @default.
• W2012127536 hasConceptScore W2012127536C62478195 @default.
• W2012127536 hasConceptScore W2012127536C86803240 @default.
• W2012127536 hasConceptScore W2012127536C95444343 @default.
• W2012127536 hasIssue "8" @default.
• W2012127536 hasLocation W20121275361 @default.
• W2012127536 hasLocation W20121275362 @default.
• W2012127536 hasOpenAccess W2012127536 @default.
• W2012127536 hasPrimaryLocation W20121275361 @default.
• W2012127536 hasRelatedWork W14061706 @default.
• W2012127536 hasRelatedWork W1871677735 @default.
• W2012127536 hasRelatedWork W2032062312 @default.
• W2012127536 hasRelatedWork W2149357045 @default.
• W2012127536 hasRelatedWork W2158460758 @default.
• W2012127536 hasRelatedWork W2523588288 @default.
• W2012127536 hasRelatedWork W2552820660 @default.
• W2012127536 hasRelatedWork W2620094379 @default.
• W2012127536 hasRelatedWork W2979508620 @default.

• next