FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012128296> ?p ?o ?g. }

• W2012128296 endingPage "1412" @default.
• W2012128296 startingPage "1403" @default.
• W2012128296 abstract "Abstract Background: Hepatic steatosis occurs in 40–70% of patients chronically infected with hepatitis C virus [chronic hepatitis C (CH‐C)]. Hepatic steatosis in CH‐C is associated with progressive liver disease and a low response rate to antiviral therapy. Aim: Gene expression profiles were examined in CH‐C patients with and without hepatic steatosis, non‐alcoholic steatohepatitis (NASH) and fibrosis. Methods: This study included 65 CH‐C patients who were not receiving antiviral treatment. Total RNA was extracted from peripheral blood mononuclear cells, quantified and used for one‐step reverse transcriptase‐polymerase chain reaction to profile 153 mRNAs that were normalized with six ‘housekeeping’ genes and a reference RNA. Multiple regression and stepwise selection assessed differences in gene expression and the models' performances were evaluated. Results: Models predicting the grade of hepatic steatosis in patients with CH‐C genotype 3 involved two genes: SOCS1 and IFITM1 , which progressively changed their expression level with the increasing grade of steatosis. On the other hand, models predicting hepatic steatosis in non‐genotype 3 patients highlighted MIP‐1 cytokine encoding genes: CCL3 and CCL4 as well as IFNAR and PRKRIR . Expression levels of PRKRIR and SMAD3 differentiated patients with and without superimposed NASH only in the non‐genotype 3 cohort (area under the receiver operating characteristic curve=0.822, P ‐value 0.006]. Gene expression signatures related to hepatic fibrosis were not genotype specific. Conclusions: Gene expression might predict moderate to severe hepatic steatosis, NASH and fibrosis in patients with CH‐C, providing potential insights into the pathogenesis of hepatic steatosis and fibrosis in these patients." @default.
• W2012128296 created "2016-06-24" @default.
• W2012128296 creator A5003434284 @default.
• W2012128296 creator A5010138815 @default.
• W2012128296 creator A5013174994 @default.
• W2012128296 creator A5045198929 @default.
• W2012128296 creator A5058695962 @default.
• W2012128296 creator A5065986636 @default.
• W2012128296 creator A5074202766 @default.
• W2012128296 creator A5080386622 @default.
• W2012128296 date "2009-09-03" @default.
• W2012128296 modified "2023-09-30" @default.
• W2012128296 title "Gene expression profile associated with superimposed non-alcoholic fatty liver disease and hepatic fibrosis in patients with chronic hepatitis C" @default.
• W2012128296 cites W1965094711 @default.
• W2012128296 cites W1966559673 @default.
• W2012128296 cites W1975805673 @default.
• W2012128296 cites W1976323775 @default.
• W2012128296 cites W1993203432 @default.
• W2012128296 cites W2004372194 @default.
• W2012128296 cites W2024227064 @default.
• W2012128296 cites W2026151480 @default.
• W2012128296 cites W2028158244 @default.
• W2012128296 cites W2030379432 @default.
• W2012128296 cites W2030893956 @default.
• W2012128296 cites W2032063778 @default.
• W2012128296 cites W2033749425 @default.
• W2012128296 cites W2041989402 @default.
• W2012128296 cites W2045084840 @default.
• W2012128296 cites W2046232763 @default.
• W2012128296 cites W2057857266 @default.
• W2012128296 cites W2094174828 @default.
• W2012128296 cites W2105249672 @default.
• W2012128296 cites W2107277218 @default.
• W2012128296 cites W2120165528 @default.
• W2012128296 cites W2138051219 @default.
• W2012128296 cites W2160315905 @default.
• W2012128296 cites W2169181757 @default.
• W2012128296 cites W39515960 @default.
• W2012128296 cites W4256582478 @default.
• W2012128296 doi "https://doi.org/10.1111/j.1478-3231.2009.02060.x" @default.
• W2012128296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19515216" @default.
• W2012128296 hasPublicationYear "2009" @default.
• W2012128296 type Work @default.
• W2012128296 sameAs 2012128296 @default.
• W2012128296 citedByCount "17" @default.
• W2012128296 countsByYear W20121282962012 @default.
• W2012128296 countsByYear W20121282962013 @default.
• W2012128296 countsByYear W20121282962014 @default.
• W2012128296 countsByYear W20121282962015 @default.
• W2012128296 countsByYear W20121282962016 @default.
• W2012128296 countsByYear W20121282962017 @default.
• W2012128296 countsByYear W20121282962019 @default.
• W2012128296 countsByYear W20121282962020 @default.
• W2012128296 countsByYear W20121282962021 @default.
• W2012128296 crossrefType "journal-article" @default.
• W2012128296 hasAuthorship W2012128296A5003434284 @default.
• W2012128296 hasAuthorship W2012128296A5010138815 @default.
• W2012128296 hasAuthorship W2012128296A5013174994 @default.
• W2012128296 hasAuthorship W2012128296A5045198929 @default.
• W2012128296 hasAuthorship W2012128296A5058695962 @default.
• W2012128296 hasAuthorship W2012128296A5065986636 @default.
• W2012128296 hasAuthorship W2012128296A5074202766 @default.
• W2012128296 hasAuthorship W2012128296A5080386622 @default.
• W2012128296 hasConcept C104317684 @default.
• W2012128296 hasConcept C126322002 @default.
• W2012128296 hasConcept C135763542 @default.
• W2012128296 hasConcept C150194340 @default.
• W2012128296 hasConcept C203014093 @default.
• W2012128296 hasConcept C2522874641 @default.
• W2012128296 hasConcept C2776175330 @default.
• W2012128296 hasConcept C2776408679 @default.
• W2012128296 hasConcept C2776455275 @default.
• W2012128296 hasConcept C2778772119 @default.
• W2012128296 hasConcept C2779134260 @default.
• W2012128296 hasConcept C2779478299 @default.
• W2012128296 hasConcept C2780559512 @default.
• W2012128296 hasConcept C2993667909 @default.
• W2012128296 hasConcept C54355233 @default.
• W2012128296 hasConcept C71924100 @default.
• W2012128296 hasConcept C86803240 @default.
• W2012128296 hasConcept C90924648 @default.
• W2012128296 hasConceptScore W2012128296C104317684 @default.
• W2012128296 hasConceptScore W2012128296C126322002 @default.
• W2012128296 hasConceptScore W2012128296C135763542 @default.
• W2012128296 hasConceptScore W2012128296C150194340 @default.
• W2012128296 hasConceptScore W2012128296C203014093 @default.
• W2012128296 hasConceptScore W2012128296C2522874641 @default.
• W2012128296 hasConceptScore W2012128296C2776175330 @default.
• W2012128296 hasConceptScore W2012128296C2776408679 @default.
• W2012128296 hasConceptScore W2012128296C2776455275 @default.
• W2012128296 hasConceptScore W2012128296C2778772119 @default.
• W2012128296 hasConceptScore W2012128296C2779134260 @default.
• W2012128296 hasConceptScore W2012128296C2779478299 @default.
• W2012128296 hasConceptScore W2012128296C2780559512 @default.
• W2012128296 hasConceptScore W2012128296C2993667909 @default.
• W2012128296 hasConceptScore W2012128296C54355233 @default.
• W2012128296 hasConceptScore W2012128296C71924100 @default.
• W2012128296 hasConceptScore W2012128296C86803240 @default.

• next