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• W2012130371 abstract "Even tough differentiated spermatozoa are unable of transcriptional or translational activity; the sperm surface undergoes major modifications in macromolecules composition during the transit along the male reproductive tract. This is the result of sequential, well orchestrated interactions between the male reproductive tract secretions and the transiting male gamete. This is particularly true when spermatozoa transit along the epididymis. The epididymis is a long convoluted tubules in which the spermatozoa leaving the testis have to transit. The unraveled epididymal tubule can be as long as 80 m in stallion, and the transit time of spermatozoa is of 3-12 days depending on the species. The epididymis is usually divided in three segments: the caput (proximal part), the corpus, and cauda. While the cauda epididymides acts as a sperm reservoir, the caput and corpus are responsible for sperm maturation. This means that, under androgen control, the epididymal epithelium secretes proteins that will interact sequentially with sperm surface. Some of the sperm proteins acquired during maturation along the excurrent duct behave as integral membrane proteins. In fact, some epididymal originating proteins are glycosylphosphatidylinositol (GPI)-anchored to the sperm plasma membrane. Our laboratory has shown that some of these proteins are secreted in an apocrine manner by the epididymal epithelium and are associated to exosomes, called epididymosomes. Epididymosomes are rich in sphingomyelin and are characterized by a high cholesterol/phospholipids ratio. Many proteins are associated to epididymosomes, some of which are selectively transferred to spermatozoa during the epididymal transit. We have identified some of these exosomes associated proteins transferred to the maturing spermatozoa. These include two enzymes involved in the polyol pathway: an aldose reductase and a sorbitol dehydrogenase. A cytokine named MIF (macrophage migration inhibitory factor) is another protein associated to exosomes who is transferred to spermatozoa during the epididymal transit. We hypothesized that both the polyol pathway and MIF secreted in an apocrine fashion by the epididymal epithelium modulate sperm motility during the transit along the male reproductive tract. Finally, P25b, belonging to a family of sperm surface proteins (P26h/P34H) necessary for the binding to the surface of the egg, is also acquired through the interaction between epididymosomes and the male gamete. In vitro studies have defined the conditions of protein transfer when epididymal spermatozoa are co-incubated with epididymosomes. The transfer of selected proteins to specific membrane domains of spermatozoa is saturable, temperature and pH-dependent, being optimal at pH 6.5. The presence of zinc in the incubation medium, but not of calcium neither magnesium, significantly increases the efficiency of protein transfer. These results show that exosomes play a role in sperm epididymal maturation which is an essential event to produce male gametes with optimal fertilizing ability." @default.
• W2012130371 created "2016-06-24" @default.
• W2012130371 creator A5027864929 @default.
• W2012130371 creator A5033860874 @default.
• W2012130371 creator A5080057246 @default.
• W2012130371 creator A5085385631 @default.
• W2012130371 date "2005-07-01" @default.
• W2012130371 modified "2023-10-14" @default.
• W2012130371 title "Role of exosomes in sperm maturation during the transit along the male reproductive tract" @default.
• W2012130371 cites W1483204570 @default.
• W2012130371 cites W1579918301 @default.
• W2012130371 cites W1701861001 @default.
• W2012130371 cites W174781154 @default.
• W2012130371 cites W1967800664 @default.
• W2012130371 cites W1967853405 @default.
• W2012130371 cites W1970996077 @default.
• W2012130371 cites W1973368196 @default.
• W2012130371 cites W1973938025 @default.
• W2012130371 cites W1974926560 @default.
• W2012130371 cites W1977269164 @default.
• W2012130371 cites W1978278349 @default.
• W2012130371 cites W1978553580 @default.
• W2012130371 cites W1979613635 @default.
• W2012130371 cites W1980906175 @default.
• W2012130371 cites W1982961997 @default.
• W2012130371 cites W1984984177 @default.
• W2012130371 cites W1988668496 @default.
• W2012130371 cites W1992726653 @default.
• W2012130371 cites W1993155998 @default.
• W2012130371 cites W2001634895 @default.
• W2012130371 cites W2005082293 @default.
• W2012130371 cites W2006060580 @default.
• W2012130371 cites W2006975807 @default.
• W2012130371 cites W2008493312 @default.
• W2012130371 cites W2009460725 @default.
• W2012130371 cites W2012252491 @default.
• W2012130371 cites W2013510288 @default.
• W2012130371 cites W2013604580 @default.
• W2012130371 cites W2015039954 @default.
• W2012130371 cites W2016819518 @default.
• W2012130371 cites W2019180841 @default.
• W2012130371 cites W2026192283 @default.
• W2012130371 cites W2027988430 @default.
• W2012130371 cites W2042309578 @default.
• W2012130371 cites W2045026009 @default.
• W2012130371 cites W2045312689 @default.
• W2012130371 cites W2049528247 @default.
• W2012130371 cites W2055199560 @default.
• W2012130371 cites W2057290809 @default.
• W2012130371 cites W2058902988 @default.
• W2012130371 cites W2061922261 @default.
• W2012130371 cites W2064719539 @default.
• W2012130371 cites W2065886456 @default.
• W2012130371 cites W2066118145 @default.
• W2012130371 cites W2066975086 @default.
• W2012130371 cites W2067852442 @default.
• W2012130371 cites W2070483818 @default.
• W2012130371 cites W2075253578 @default.
• W2012130371 cites W2075652088 @default.
• W2012130371 cites W2076316146 @default.
• W2012130371 cites W2084202474 @default.
• W2012130371 cites W2085476729 @default.
• W2012130371 cites W2086358590 @default.
• W2012130371 cites W2091843594 @default.
• W2012130371 cites W2094891724 @default.
• W2012130371 cites W2095253356 @default.
• W2012130371 cites W2096500722 @default.
• W2012130371 cites W2098557418 @default.
• W2012130371 cites W2107885286 @default.
• W2012130371 cites W2111547224 @default.
• W2012130371 cites W2114195085 @default.
• W2012130371 cites W2118569411 @default.
• W2012130371 cites W2119280818 @default.
• W2012130371 cites W2119938693 @default.
• W2012130371 cites W2120754722 @default.
• W2012130371 cites W2121936687 @default.
• W2012130371 cites W2122882997 @default.
• W2012130371 cites W2124089989 @default.
• W2012130371 cites W2128450298 @default.
• W2012130371 cites W2131926714 @default.
• W2012130371 cites W2132620108 @default.
• W2012130371 cites W2133560592 @default.
• W2012130371 cites W2135150992 @default.
• W2012130371 cites W2136855963 @default.
• W2012130371 cites W2137051799 @default.
• W2012130371 cites W2137861751 @default.
• W2012130371 cites W2144595951 @default.
• W2012130371 cites W2150745254 @default.
• W2012130371 cites W2150771937 @default.
• W2012130371 cites W2151079138 @default.
• W2012130371 cites W2151264312 @default.
• W2012130371 cites W2154061885 @default.
• W2012130371 cites W2155670123 @default.
• W2012130371 cites W2156511186 @default.
• W2012130371 cites W2165626488 @default.
• W2012130371 cites W2167232017 @default.
• W2012130371 cites W2168456331 @default.
• W2012130371 cites W2276004791 @default.

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