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- W2012130573 abstract "Background . The impact of hepatic steatosis on outcome following hepatic ischemia-reperfusion injury (IRI) remains controversial with conflicting clinical results. A number of experimental studies have been published examining the relationship between hepatic steatosis and IRI. This systematic review evaluates these experimental studies. Methods . An electronic search of the Medline and Embase databases (January 1946 to June 2012) was performed to identify studies that reported relevant outcomes in animal models of hepatic steatosis subjected to IRI. Results . A total of 1314 articles were identified, of which 33 met the predefined criteria and were included in the study. There was large variation in the type of animal model, duration, and type of IRI and reporting of histological findings. Increased macrovesicular steatosis (>30%) was associated with increased histological damage, liver function derangement, and reduced survival. Increased duration of warm or cold ischemia had a negative impact on all outcomes measured. Microvesicular steatosis did not influence outcome. Conclusions . Findings from this systemic review support the hypothesis that livers with >30% macrovesicular steatosis are less tolerant of IRI. Clinically, it is likely that these findings are applicable to patients undergoing hepatic resection, but further studies are required to confirm these data." @default.
- W2012130573 created "2016-06-24" @default.
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- W2012130573 creator A5061751601 @default.
- W2012130573 creator A5065296918 @default.
- W2012130573 creator A5080911705 @default.
- W2012130573 date "2013-01-01" @default.
- W2012130573 modified "2023-10-18" @default.
- W2012130573 title "The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review" @default.
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- W2012130573 doi "https://doi.org/10.1155/2013/192029" @default.
- W2012130573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3766550" @default.
- W2012130573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24062999" @default.
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