FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012131775> ?p ?o ?g. }

• W2012131775 endingPage "1301" @default.
• W2012131775 startingPage "1295" @default.
• W2012131775 abstract "Abstract: It was shown previously that the tridecapeptide neurotensin is inactivated by rat brain synaptic membranes and that one of the primary inactivating cleavages occurs at the Pro10-Tyr11 peptide bond, leading to the formation of NT1–10 and NT11–13.The present study was designed to investigate the possibility that this cleavage was catalyzed by proline endopeptidase and/or endopeptidase 24.11 (enkephalinase). Purified rat brain synaptic membranes were found to contain a N-benzyloxycarbonyl-Gly-Pro-4-methyl-coumarinyl-7-amide-hydrolyzing activity that was markedly inhibited (93%) by the proline endopeptidase inhibitor N-benzyloxycarbonyl-Pro-Prolinal and partially blocked (25%) by an antiproline endopeptidase antiserum. In contrast, the cleavage of neurotensin at the Pro10-Tyr11 bond by synaptic membranes was not affected by N-benzyloxycarbonyl-Pro-Prolinal and the antiserum. When the conversion of NT1–10 to NT1–8 by angiotensin converting enzyme was blocked by captopril and when the processing of NT11–13 by aminopeptidase(s) was inhibited by bestatin, it was found that thiorphan, a potent endopeptidase 24.11 inhibitor, partially decreased the formation of NT1–10 and NT11–13 by synaptic membranes. In conclusion: (1) proline endopeptidase, although it is present in synaptic membranes, is not involved in the cleavage of neurotensin at the Pro10-Tyr11 bond; (2) endopeptidase 24.11 only partially contributes to this cleavage; (3) there exists in rat brain synaptic membranes a peptidase different from proline endopeptidase and endopeptidase 24.11 that is mainly responsible for inactivating neurotensin by cleaving at the Pro10-Tyr11 bond." @default.
• W2012131775 created "2016-06-24" @default.
• W2012131775 creator A5029529474 @default.
• W2012131775 creator A5064226857 @default.
• W2012131775 creator A5086409965 @default.
• W2012131775 creator A5088188549 @default.
• W2012131775 date "1984-11-01" @default.
• W2012131775 modified "2023-10-16" @default.
• W2012131775 title "Inactivation of Neurotensin by Rat Brain Synaptic Membranes. Cleavage at the Pro¹⁰-Tyr¹¹Bond by Endopeptidase 24.11 (Enkephalinase) and a Peptidase Different from Proline-Endopeptidase" @default.
• W2012131775 cites W1490343157 @default.
• W2012131775 cites W1519355795 @default.
• W2012131775 cites W1543111690 @default.
• W2012131775 cites W1560419375 @default.
• W2012131775 cites W1835492539 @default.
• W2012131775 cites W1965686429 @default.
• W2012131775 cites W1980623360 @default.
• W2012131775 cites W1987341100 @default.
• W2012131775 cites W1988295650 @default.
• W2012131775 cites W1990401947 @default.
• W2012131775 cites W1998838720 @default.
• W2012131775 cites W2000314850 @default.
• W2012131775 cites W2001684606 @default.
• W2012131775 cites W2002510735 @default.
• W2012131775 cites W2002775774 @default.
• W2012131775 cites W2010280935 @default.
• W2012131775 cites W2020689975 @default.
• W2012131775 cites W2022221734 @default.
• W2012131775 cites W2031825797 @default.
• W2012131775 cites W2032424720 @default.
• W2012131775 cites W2033072861 @default.
• W2012131775 cites W2052669976 @default.
• W2012131775 cites W2060843858 @default.
• W2012131775 cites W2061123970 @default.
• W2012131775 cites W2069920566 @default.
• W2012131775 cites W2076135612 @default.
• W2012131775 cites W2077786122 @default.
• W2012131775 cites W2081493827 @default.
• W2012131775 cites W2082301907 @default.
• W2012131775 cites W2168110475 @default.
• W2012131775 cites W2229489514 @default.
• W2012131775 cites W2949698826 @default.
• W2012131775 doi "https://doi.org/10.1111/j.1471-4159.1984.tb05386.x" @default.
• W2012131775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6387047" @default.
• W2012131775 hasPublicationYear "1984" @default.
• W2012131775 type Work @default.
• W2012131775 sameAs 2012131775 @default.
• W2012131775 citedByCount "74" @default.
• W2012131775 countsByYear W20121317752012 @default.
• W2012131775 countsByYear W20121317752013 @default.
• W2012131775 countsByYear W20121317752014 @default.
• W2012131775 countsByYear W20121317752018 @default.
• W2012131775 countsByYear W20121317752020 @default.
• W2012131775 countsByYear W20121317752021 @default.
• W2012131775 crossrefType "journal-article" @default.
• W2012131775 hasAuthorship W2012131775A5029529474 @default.
• W2012131775 hasAuthorship W2012131775A5064226857 @default.
• W2012131775 hasAuthorship W2012131775A5086409965 @default.
• W2012131775 hasAuthorship W2012131775A5088188549 @default.
• W2012131775 hasConcept C104826730 @default.
• W2012131775 hasConcept C118303440 @default.
• W2012131775 hasConcept C170493617 @default.
• W2012131775 hasConcept C181199279 @default.
• W2012131775 hasConcept C185592680 @default.
• W2012131775 hasConcept C2776775109 @default.
• W2012131775 hasConcept C2777774944 @default.
• W2012131775 hasConcept C2777803847 @default.
• W2012131775 hasConcept C2778976297 @default.
• W2012131775 hasConcept C2780919550 @default.
• W2012131775 hasConcept C2781063702 @default.
• W2012131775 hasConcept C2781372283 @default.
• W2012131775 hasConcept C31684184 @default.
• W2012131775 hasConcept C41625074 @default.
• W2012131775 hasConcept C55493867 @default.
• W2012131775 hasConcept C86803240 @default.
• W2012131775 hasConceptScore W2012131775C104826730 @default.
• W2012131775 hasConceptScore W2012131775C118303440 @default.
• W2012131775 hasConceptScore W2012131775C170493617 @default.
• W2012131775 hasConceptScore W2012131775C181199279 @default.
• W2012131775 hasConceptScore W2012131775C185592680 @default.
• W2012131775 hasConceptScore W2012131775C2776775109 @default.
• W2012131775 hasConceptScore W2012131775C2777774944 @default.
• W2012131775 hasConceptScore W2012131775C2777803847 @default.
• W2012131775 hasConceptScore W2012131775C2778976297 @default.
• W2012131775 hasConceptScore W2012131775C2780919550 @default.
• W2012131775 hasConceptScore W2012131775C2781063702 @default.
• W2012131775 hasConceptScore W2012131775C2781372283 @default.
• W2012131775 hasConceptScore W2012131775C31684184 @default.
• W2012131775 hasConceptScore W2012131775C41625074 @default.
• W2012131775 hasConceptScore W2012131775C55493867 @default.
• W2012131775 hasConceptScore W2012131775C86803240 @default.
• W2012131775 hasIssue "5" @default.
• W2012131775 hasLocation W20121317751 @default.
• W2012131775 hasLocation W20121317752 @default.
• W2012131775 hasOpenAccess W2012131775 @default.
• W2012131775 hasPrimaryLocation W20121317751 @default.
• W2012131775 hasRelatedWork W1966793722 @default.
• W2012131775 hasRelatedWork W1975029183 @default.
• W2012131775 hasRelatedWork W1985513416 @default.

• next