Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012131806> ?p ?o ?g. }
- W2012131806 endingPage "531" @default.
- W2012131806 startingPage "523" @default.
- W2012131806 abstract "Sarcopenia is the age-related loss of muscle mass, strength and function. Human muscle proteins are synthesized at a slower rate in the elderly than in young adults, leading to atrophy and muscle mass loss with a decline in the functional capability. Additionally, aging is accompanied by a decrease in the ability of muscle tissue to regenerate following injury or overuse due to the impairment of intervening satellite cells, in which we previously reported oxidative damage evidences. The aim of the present study was to determine the effects of aging on myoblasts and myotubes obtained from human skeletal muscle, and characterize the transcriptional profile as molecular expression patterns in relation to age-dependent modifications in their regenerative capacity. Our data show that the failure to differentiate does not depend on reduced myogenic cell number, but difficulty to complete the differentiation program. Data reported here suggested the following findings: (i) oxidative damage accumulation in molecular substrates, probably due to impaired antioxidant activity and insufficient repair capability, (ii) limited capability of elderly myoblasts to execute a complete differentiation program; restricted fusion, possibly due to altered cytoskeleton turnover and extracellular matrix degradation and (iii) activation of atrophy mechanism by activation of a specific FOXO-dependent program." @default.
- W2012131806 created "2016-06-24" @default.
- W2012131806 creator A5025192733 @default.
- W2012131806 creator A5055968688 @default.
- W2012131806 creator A5056215144 @default.
- W2012131806 creator A5058079163 @default.
- W2012131806 creator A5066242737 @default.
- W2012131806 creator A5074725692 @default.
- W2012131806 date "2009-08-01" @default.
- W2012131806 modified "2023-10-14" @default.
- W2012131806 title "Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation" @default.
- W2012131806 cites W142443555 @default.
- W2012131806 cites W1930333778 @default.
- W2012131806 cites W1965069951 @default.
- W2012131806 cites W1969246208 @default.
- W2012131806 cites W1969332657 @default.
- W2012131806 cites W1972882792 @default.
- W2012131806 cites W1975153661 @default.
- W2012131806 cites W1975811251 @default.
- W2012131806 cites W1984419476 @default.
- W2012131806 cites W1992384426 @default.
- W2012131806 cites W1994016632 @default.
- W2012131806 cites W2001969764 @default.
- W2012131806 cites W2007739207 @default.
- W2012131806 cites W2008628228 @default.
- W2012131806 cites W2017429680 @default.
- W2012131806 cites W2019319064 @default.
- W2012131806 cites W2019738475 @default.
- W2012131806 cites W2024013299 @default.
- W2012131806 cites W202963727 @default.
- W2012131806 cites W2033797333 @default.
- W2012131806 cites W2034114409 @default.
- W2012131806 cites W2035596000 @default.
- W2012131806 cites W2041859052 @default.
- W2012131806 cites W2045934419 @default.
- W2012131806 cites W2051071881 @default.
- W2012131806 cites W2053827264 @default.
- W2012131806 cites W2056244848 @default.
- W2012131806 cites W2057396209 @default.
- W2012131806 cites W2058902172 @default.
- W2012131806 cites W2059186500 @default.
- W2012131806 cites W2063881294 @default.
- W2012131806 cites W2064683528 @default.
- W2012131806 cites W2069032421 @default.
- W2012131806 cites W2070667194 @default.
- W2012131806 cites W2075151495 @default.
- W2012131806 cites W2077102648 @default.
- W2012131806 cites W2077250547 @default.
- W2012131806 cites W2085272153 @default.
- W2012131806 cites W2087803244 @default.
- W2012131806 cites W2092490000 @default.
- W2012131806 cites W2093306205 @default.
- W2012131806 cites W2095606469 @default.
- W2012131806 cites W2102837285 @default.
- W2012131806 cites W2104317289 @default.
- W2012131806 cites W2105199683 @default.
- W2012131806 cites W2107919301 @default.
- W2012131806 cites W2116382217 @default.
- W2012131806 cites W2119290720 @default.
- W2012131806 cites W2123780581 @default.
- W2012131806 cites W2124150189 @default.
- W2012131806 cites W2124782955 @default.
- W2012131806 cites W2124959176 @default.
- W2012131806 cites W2127144515 @default.
- W2012131806 cites W2133044222 @default.
- W2012131806 cites W2133918998 @default.
- W2012131806 cites W2154826115 @default.
- W2012131806 cites W2169367947 @default.
- W2012131806 cites W2169788367 @default.
- W2012131806 cites W2176985336 @default.
- W2012131806 cites W2223742570 @default.
- W2012131806 cites W2390642446 @default.
- W2012131806 cites W2766032112 @default.
- W2012131806 doi "https://doi.org/10.1016/j.exger.2009.05.002" @default.
- W2012131806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19457451" @default.
- W2012131806 hasPublicationYear "2009" @default.
- W2012131806 type Work @default.
- W2012131806 sameAs 2012131806 @default.
- W2012131806 citedByCount "81" @default.
- W2012131806 countsByYear W20121318062012 @default.
- W2012131806 countsByYear W20121318062013 @default.
- W2012131806 countsByYear W20121318062014 @default.
- W2012131806 countsByYear W20121318062015 @default.
- W2012131806 countsByYear W20121318062016 @default.
- W2012131806 countsByYear W20121318062017 @default.
- W2012131806 countsByYear W20121318062018 @default.
- W2012131806 countsByYear W20121318062019 @default.
- W2012131806 countsByYear W20121318062020 @default.
- W2012131806 countsByYear W20121318062021 @default.
- W2012131806 countsByYear W20121318062022 @default.
- W2012131806 countsByYear W20121318062023 @default.
- W2012131806 crossrefType "journal-article" @default.
- W2012131806 hasAuthorship W2012131806A5025192733 @default.
- W2012131806 hasAuthorship W2012131806A5055968688 @default.
- W2012131806 hasAuthorship W2012131806A5056215144 @default.
- W2012131806 hasAuthorship W2012131806A5058079163 @default.
- W2012131806 hasAuthorship W2012131806A5066242737 @default.
- W2012131806 hasAuthorship W2012131806A5074725692 @default.