Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012132832> ?p ?o ?g. }
- W2012132832 endingPage "182" @default.
- W2012132832 startingPage "175" @default.
- W2012132832 abstract "Preeclampsia is a major disease of human pregnancy characterised by hypertension and proteinuria. These signs are preceded by systemic maternal endothelial dysfunction. Hypertension in preeclampsia appears to be triggered by a placental factor, which leads to endothelial activation/dysfunction. One potential placental trigger for preeclampsia is necrotic trophoblast cell debris shed from the placenta into maternal blood. The larger trophoblast debris is trapped in the maternal pulmonary vessels and is hypothesised to be cleared by endothelial cells. Phagocytosis of necrotic but not apoptotic trophoblast debris by endothelial cells leads to their activation in vitro. We hypothesised that intravenous injection of necrotic trophoblast debris would induce hypertension in pregnant rats. Virgin female Wistar rats were surgically implanted with telemetry devices to monitor arterial blood pressure and chronic intravenous catheters to allow delivery of necrotic trophoblast debris. After recovery, the rats were mated and, from day 6 of gestation until parturition, they were given five consecutive daily injections per week of 5×10(6) necrotic Jeg-3 cells per kilo bodyweight. Control rats received vehicle injections. The normalised mean arterial blood pressure of rats receiving injections of necrotic trophoblast debris was higher than control rats during the third week of gestation, while mean arterial blood pressure decreased less from the pre-pregnancy baseline compared to control rats. These results suggest that necrotic trophoblast debris has a hypertensive effect which manifests in late gestation in Wistar rats and supports the theory that necrotic trophoblast debris may trigger the symptoms of preeclampsia." @default.
- W2012132832 created "2016-06-24" @default.
- W2012132832 creator A5015761832 @default.
- W2012132832 creator A5053201436 @default.
- W2012132832 creator A5081650366 @default.
- W2012132832 creator A5091493166 @default.
- W2012132832 date "2013-04-01" @default.
- W2012132832 modified "2023-10-02" @default.
- W2012132832 title "Necrotic trophoblast debris increases blood pressure during pregnancy" @default.
- W2012132832 cites W1490812480 @default.
- W2012132832 cites W178827369 @default.
- W2012132832 cites W1967258935 @default.
- W2012132832 cites W1982291791 @default.
- W2012132832 cites W1991266906 @default.
- W2012132832 cites W1993234733 @default.
- W2012132832 cites W1999061952 @default.
- W2012132832 cites W2001794634 @default.
- W2012132832 cites W2029341266 @default.
- W2012132832 cites W2031604786 @default.
- W2012132832 cites W2032943068 @default.
- W2012132832 cites W2041862015 @default.
- W2012132832 cites W2061506872 @default.
- W2012132832 cites W2062943600 @default.
- W2012132832 cites W2064737612 @default.
- W2012132832 cites W2069229861 @default.
- W2012132832 cites W2069323661 @default.
- W2012132832 cites W2070638559 @default.
- W2012132832 cites W2071524539 @default.
- W2012132832 cites W2074369882 @default.
- W2012132832 cites W2079944017 @default.
- W2012132832 cites W2080399103 @default.
- W2012132832 cites W2097292741 @default.
- W2012132832 cites W2102881826 @default.
- W2012132832 cites W2116702282 @default.
- W2012132832 cites W2120006904 @default.
- W2012132832 cites W2132577797 @default.
- W2012132832 cites W2134318304 @default.
- W2012132832 cites W2137175883 @default.
- W2012132832 cites W2142726621 @default.
- W2012132832 cites W2147636600 @default.
- W2012132832 cites W2147994749 @default.
- W2012132832 cites W2153569707 @default.
- W2012132832 cites W2155694561 @default.
- W2012132832 cites W2159442474 @default.
- W2012132832 cites W2159621826 @default.
- W2012132832 cites W2160033773 @default.
- W2012132832 cites W2160230584 @default.
- W2012132832 cites W2160513558 @default.
- W2012132832 cites W2161245251 @default.
- W2012132832 cites W2161723637 @default.
- W2012132832 cites W2166420602 @default.
- W2012132832 cites W2197210544 @default.
- W2012132832 doi "https://doi.org/10.1016/j.jri.2012.12.005" @default.
- W2012132832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23485144" @default.
- W2012132832 hasPublicationYear "2013" @default.
- W2012132832 type Work @default.
- W2012132832 sameAs 2012132832 @default.
- W2012132832 citedByCount "23" @default.
- W2012132832 countsByYear W20121328322014 @default.
- W2012132832 countsByYear W20121328322015 @default.
- W2012132832 countsByYear W20121328322016 @default.
- W2012132832 countsByYear W20121328322017 @default.
- W2012132832 countsByYear W20121328322018 @default.
- W2012132832 countsByYear W20121328322020 @default.
- W2012132832 countsByYear W20121328322021 @default.
- W2012132832 countsByYear W20121328322022 @default.
- W2012132832 countsByYear W20121328322023 @default.
- W2012132832 crossrefType "journal-article" @default.
- W2012132832 hasAuthorship W2012132832A5015761832 @default.
- W2012132832 hasAuthorship W2012132832A5053201436 @default.
- W2012132832 hasAuthorship W2012132832A5081650366 @default.
- W2012132832 hasAuthorship W2012132832A5091493166 @default.
- W2012132832 hasConcept C126322002 @default.
- W2012132832 hasConcept C134018914 @default.
- W2012132832 hasConcept C16685009 @default.
- W2012132832 hasConcept C172680121 @default.
- W2012132832 hasConcept C2776953305 @default.
- W2012132832 hasConcept C2777218350 @default.
- W2012132832 hasConcept C2777495146 @default.
- W2012132832 hasConcept C2779234561 @default.
- W2012132832 hasConcept C46973012 @default.
- W2012132832 hasConcept C54355233 @default.
- W2012132832 hasConcept C71924100 @default.
- W2012132832 hasConcept C84393581 @default.
- W2012132832 hasConcept C86803240 @default.
- W2012132832 hasConceptScore W2012132832C126322002 @default.
- W2012132832 hasConceptScore W2012132832C134018914 @default.
- W2012132832 hasConceptScore W2012132832C16685009 @default.
- W2012132832 hasConceptScore W2012132832C172680121 @default.
- W2012132832 hasConceptScore W2012132832C2776953305 @default.
- W2012132832 hasConceptScore W2012132832C2777218350 @default.
- W2012132832 hasConceptScore W2012132832C2777495146 @default.
- W2012132832 hasConceptScore W2012132832C2779234561 @default.
- W2012132832 hasConceptScore W2012132832C46973012 @default.
- W2012132832 hasConceptScore W2012132832C54355233 @default.
- W2012132832 hasConceptScore W2012132832C71924100 @default.
- W2012132832 hasConceptScore W2012132832C84393581 @default.
- W2012132832 hasConceptScore W2012132832C86803240 @default.