Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012133038> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2012133038 endingPage "e55" @default.
- W2012133038 startingPage "e50" @default.
- W2012133038 abstract "Prostate cancer (PrCa) remains a major public health burden worldwide. Screening programs have been established using the most efficient biomarker to date—prostate-specific antigen (PSA)—with the goal of earlier detection of this disease, which is thought to translate to a reduction in PrCa mortality. However, these screening programs have proved to be controversial following the publication of the two large, randomized, population-based studies in the United States and Europe. There is a recognized need for more refined screening strategies to address some of the deficiencies highlighted in these trials, which include the overdiagnosis and overtreatment of clinically indolent disease. One such strategy could be to include inherited genetic variants in population risk stratification to identify those at higher risk who might benefit more from screening. The genetic component for PrCa risk has been documented from case control and twin studies. The genetic variants include common variants discovered by genome-wide association studies (GWAS). However, their clinical application—including their utility in screening programs—is as yet undefined. There are, however, moderate to rare genetic variants, which confer a much higher risk of PrCa (e.g., BRCA1/2 and mismatch repair [MMR] repair genes). There is more research evidence on the clinical effect of germ-line mutations in these genes; mutation carriers are more likely to develop aggressive PrCa with worse survival. A targeted screening approach might be beneficial if earlier diagnosis, and hence treatment, was to translate into improved outcomes. Clinical trials are currently underway to investigate this further." @default.
- W2012133038 created "2016-06-24" @default.
- W2012133038 creator A5011222815 @default.
- W2012133038 creator A5045362595 @default.
- W2012133038 creator A5077861800 @default.
- W2012133038 date "2013-01-01" @default.
- W2012133038 modified "2023-09-27" @default.
- W2012133038 title "Prostate Cancer Screening in BRCA and Lynch Syndrome Mutation Carriers" @default.
- W2012133038 doi "https://doi.org/10.1200/edbook_am.2013.33.e50" @default.
- W2012133038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23714454" @default.
- W2012133038 hasPublicationYear "2013" @default.
- W2012133038 type Work @default.
- W2012133038 sameAs 2012133038 @default.
- W2012133038 citedByCount "10" @default.
- W2012133038 countsByYear W20121330382013 @default.
- W2012133038 countsByYear W20121330382014 @default.
- W2012133038 countsByYear W20121330382015 @default.
- W2012133038 countsByYear W20121330382016 @default.
- W2012133038 countsByYear W20121330382017 @default.
- W2012133038 countsByYear W20121330382018 @default.
- W2012133038 countsByYear W20121330382021 @default.
- W2012133038 crossrefType "journal-article" @default.
- W2012133038 hasAuthorship W2012133038A5011222815 @default.
- W2012133038 hasAuthorship W2012133038A5045362595 @default.
- W2012133038 hasAuthorship W2012133038A5077861800 @default.
- W2012133038 hasBestOaLocation W20121330381 @default.
- W2012133038 hasConcept C121608353 @default.
- W2012133038 hasConcept C126322002 @default.
- W2012133038 hasConcept C143998085 @default.
- W2012133038 hasConcept C2775941076 @default.
- W2012133038 hasConcept C2776559941 @default.
- W2012133038 hasConcept C2779134260 @default.
- W2012133038 hasConcept C2779377019 @default.
- W2012133038 hasConcept C2780192828 @default.
- W2012133038 hasConcept C2780673598 @default.
- W2012133038 hasConcept C2781406297 @default.
- W2012133038 hasConcept C2908647359 @default.
- W2012133038 hasConcept C526805850 @default.
- W2012133038 hasConcept C535046627 @default.
- W2012133038 hasConcept C60644358 @default.
- W2012133038 hasConcept C60748783 @default.
- W2012133038 hasConcept C71924100 @default.
- W2012133038 hasConcept C86803240 @default.
- W2012133038 hasConcept C99454951 @default.
- W2012133038 hasConceptScore W2012133038C121608353 @default.
- W2012133038 hasConceptScore W2012133038C126322002 @default.
- W2012133038 hasConceptScore W2012133038C143998085 @default.
- W2012133038 hasConceptScore W2012133038C2775941076 @default.
- W2012133038 hasConceptScore W2012133038C2776559941 @default.
- W2012133038 hasConceptScore W2012133038C2779134260 @default.
- W2012133038 hasConceptScore W2012133038C2779377019 @default.
- W2012133038 hasConceptScore W2012133038C2780192828 @default.
- W2012133038 hasConceptScore W2012133038C2780673598 @default.
- W2012133038 hasConceptScore W2012133038C2781406297 @default.
- W2012133038 hasConceptScore W2012133038C2908647359 @default.
- W2012133038 hasConceptScore W2012133038C526805850 @default.
- W2012133038 hasConceptScore W2012133038C535046627 @default.
- W2012133038 hasConceptScore W2012133038C60644358 @default.
- W2012133038 hasConceptScore W2012133038C60748783 @default.
- W2012133038 hasConceptScore W2012133038C71924100 @default.
- W2012133038 hasConceptScore W2012133038C86803240 @default.
- W2012133038 hasConceptScore W2012133038C99454951 @default.
- W2012133038 hasLocation W20121330381 @default.
- W2012133038 hasOpenAccess W2012133038 @default.
- W2012133038 hasPrimaryLocation W20121330381 @default.
- W2012133038 hasRelatedWork W103670294 @default.
- W2012133038 hasRelatedWork W2057960756 @default.
- W2012133038 hasRelatedWork W2109046819 @default.
- W2012133038 hasRelatedWork W2171626530 @default.
- W2012133038 hasRelatedWork W2415692930 @default.
- W2012133038 hasRelatedWork W2526330449 @default.
- W2012133038 hasRelatedWork W2885626395 @default.
- W2012133038 hasRelatedWork W2966258052 @default.
- W2012133038 hasRelatedWork W4242730600 @default.
- W2012133038 hasRelatedWork W4280590802 @default.
- W2012133038 hasVolume "33" @default.
- W2012133038 isParatext "false" @default.
- W2012133038 isRetracted "false" @default.
- W2012133038 magId "2012133038" @default.
- W2012133038 workType "article" @default.