FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012133308> ?p ?o ?g. }

• W2012133308 endingPage "297" @default.
• W2012133308 startingPage "283" @default.
• W2012133308 abstract "Signal transduction networks have only been studied at a small scale because large-scale reconstructions and suitable in silico analysis methods have not been available. Since reconstructions of large signaling networks are progressing well there is now a need to develop a framework for analysing structural properties of signaling networks. One such framework is presented here, one that is based on systemically independent pathways and a mass-balanced representation of signaling events. This approach was applied to a prototypic signaling network and it allowed for: (1) a systemic analysis of all possible input/output relationships, (2) a quantitative evaluation of network crosstalk, or the interconnectivity of systemically independent pathways, (3) a measure of the redundancy in the signaling network, (4) the participation of reactions in signaling pathways, and (5) the calculation of correlated reaction sets. These properties emerge from network structure and can only be derived and studied within a defined mathematical framework. The calculations presented are the first of their kind for a signaling network, while similar analysis has been extensively performed for prototypic and genome-scale metabolic networks. This approach does not yet account for dynamic concentration profiles. Due to the scalability of the stoichiometric formalism used, the results presented for the prototypic signaling network can be obtained for large signaling networks once their reconstruction is completed." @default.
• W2012133308 created "2016-06-24" @default.
• W2012133308 creator A5000119406 @default.
• W2012133308 creator A5051097609 @default.
• W2012133308 date "2004-03-01" @default.
• W2012133308 modified "2023-09-27" @default.
• W2012133308 title "Topological analysis of mass-balanced signaling networks: a framework to obtain network properties including crosstalk" @default.
• W2012133308 cites W1501469166 @default.
• W2012133308 cites W1524662923 @default.
• W2012133308 cites W1553833389 @default.
• W2012133308 cites W1623155147 @default.
• W2012133308 cites W1637936532 @default.
• W2012133308 cites W1641228030 @default.
• W2012133308 cites W1758395617 @default.
• W2012133308 cites W1873506857 @default.
• W2012133308 cites W1946177469 @default.
• W2012133308 cites W1964491374 @default.
• W2012133308 cites W1966392395 @default.
• W2012133308 cites W1967525449 @default.
• W2012133308 cites W1967826305 @default.
• W2012133308 cites W1978393771 @default.
• W2012133308 cites W1980396134 @default.
• W2012133308 cites W1987198680 @default.
• W2012133308 cites W1989712725 @default.
• W2012133308 cites W1994656497 @default.
• W2012133308 cites W1996356699 @default.
• W2012133308 cites W2012459591 @default.
• W2012133308 cites W2018591360 @default.
• W2012133308 cites W2022440628 @default.
• W2012133308 cites W2024963167 @default.
• W2012133308 cites W2036618934 @default.
• W2012133308 cites W2037614307 @default.
• W2012133308 cites W2037718952 @default.
• W2012133308 cites W2039419058 @default.
• W2012133308 cites W2042605932 @default.
• W2012133308 cites W2046254395 @default.
• W2012133308 cites W2047228180 @default.
• W2012133308 cites W2063354556 @default.
• W2012133308 cites W2063475537 @default.
• W2012133308 cites W2071902637 @default.
• W2012133308 cites W2075161553 @default.
• W2012133308 cites W2080372560 @default.
• W2012133308 cites W2082209194 @default.
• W2012133308 cites W2086801902 @default.
• W2012133308 cites W2089441381 @default.
• W2012133308 cites W2094399313 @default.
• W2012133308 cites W2094703210 @default.
• W2012133308 cites W2098709515 @default.
• W2012133308 cites W2103565638 @default.
• W2012133308 cites W2106374727 @default.
• W2012133308 cites W2107333582 @default.
• W2012133308 cites W2117486132 @default.
• W2012133308 cites W2139439234 @default.
• W2012133308 cites W2140403455 @default.
• W2012133308 cites W2148190806 @default.
• W2012133308 cites W2165641442 @default.
• W2012133308 cites W2171429717 @default.
• W2012133308 cites W3103786587 @default.
• W2012133308 doi "https://doi.org/10.1016/j.jtbi.2003.11.016" @default.
• W2012133308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14990392" @default.
• W2012133308 hasPublicationYear "2004" @default.
• W2012133308 type Work @default.
• W2012133308 sameAs 2012133308 @default.
• W2012133308 citedByCount "95" @default.
• W2012133308 countsByYear W20121333082012 @default.
• W2012133308 countsByYear W20121333082013 @default.
• W2012133308 countsByYear W20121333082014 @default.
• W2012133308 countsByYear W20121333082015 @default.
• W2012133308 countsByYear W20121333082016 @default.
• W2012133308 countsByYear W20121333082017 @default.
• W2012133308 countsByYear W20121333082018 @default.
• W2012133308 countsByYear W20121333082020 @default.
• W2012133308 countsByYear W20121333082021 @default.
• W2012133308 countsByYear W20121333082022 @default.
• W2012133308 crossrefType "journal-article" @default.
• W2012133308 hasAuthorship W2012133308A5000119406 @default.
• W2012133308 hasAuthorship W2012133308A5051097609 @default.
• W2012133308 hasConcept C104317684 @default.
• W2012133308 hasConcept C111919701 @default.
• W2012133308 hasConcept C114614502 @default.
• W2012133308 hasConcept C120314980 @default.
• W2012133308 hasConcept C121332964 @default.
• W2012133308 hasConcept C127413603 @default.
• W2012133308 hasConcept C150555746 @default.
• W2012133308 hasConcept C152124472 @default.
• W2012133308 hasConcept C152662350 @default.
• W2012133308 hasConcept C154945302 @default.
• W2012133308 hasConcept C169822122 @default.
• W2012133308 hasConcept C184720557 @default.
• W2012133308 hasConcept C24326235 @default.
• W2012133308 hasConcept C25516864 @default.
• W2012133308 hasConcept C2775905019 @default.
• W2012133308 hasConcept C28225019 @default.
• W2012133308 hasConcept C2994130171 @default.
• W2012133308 hasConcept C32946077 @default.
• W2012133308 hasConcept C33923547 @default.
• W2012133308 hasConcept C41008148 @default.
• W2012133308 hasConcept C48044578 @default.

• next