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• W2012133925 abstract "The neurological manifestations of Fabry disease include severe episodes of lancinating pain and burning paraesthesias in the extremities, often triggered by changes in temperature. The preferential involvement of small nerve fibres and the accumulation of storage product in the central autonomic nervous system and autonomic ganglia means that standard neurophysiological procedures cannot adequately evaluate the peripheral and autonomic nervous systems of affected patients. This paper describes the various methods that have been developed to assess impairment of temperature perception, vibratory perception, sudomotor and sweat gland function, and limb and superficial skin blood flow and vasoreactivity. These methods, including thermal provocation tests, quantitative sudomotor axon reflex testing and venous occlussion plethsmography, have been used effectively in patients with Fabry disease to measure the extent of neurological dysfunction.Effective methods for measuring neurological involvement in patients with Fabry disease have been developed. These methods will be valuable in assessing the response of patients to enzyme replacement therapy." @default.
• W2012133925 created "2016-06-24" @default.
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• W2012133925 date "2002-11-01" @default.
• W2012133925 modified "2023-09-27" @default.
• W2012133925 title "Evaluation of peripheral and autonomic nerve function in Fabry disease" @default.
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• W2012133925 doi "https://doi.org/10.1111/j.1651-2227.2002.tb03108.x" @default.
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