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- W2012135018 startingPage "128" @default.
- W2012135018 abstract "Glial tumors have demonstrated abilities to sustain growth via recruitment of glial progenitor cells (GPCs), which is believed to be driven by chemotactic cues. Previous studies have illustrated that mouse GPCs of different genetic backgrounds are able to replicate the dispersion pattern seen in the human disease. How GPCs with genetic backgrounds transformed by tumor paracrine signaling respond to extracellular cues via migration is largely unexplored, and remains a limiting factor in utilizing GPCs as therapeutic targets. In this study, we utilized a microfluidic device to examine the chemotaxis of three genetically-altered mouse GPC populations towards tumor conditioned media, as well as towards three growth factors known to initiate the chemotaxis of cells excised from glial tumors: Hepatocyte Growth Factor (HGF), Platelet-Derived Growth Factor-BB (PDGF-BB), and Transforming Growth Factor-α (TGF-α). Our results illustrate that GPC types studied exhibited chemoattraction and chemorepulsion by different concentrations of the same ligand, as well as enhanced migration in the presence of ultra-low ligand concentrations within environments of high concentration gradient. These findings contribute towards our understanding of the causative and supportive roles that GPCs play in tumor growth and reoccurrence, and also point to GPCs as potential therapeutic targets for glioma treatment." @default.
- W2012135018 created "2016-06-24" @default.
- W2012135018 creator A5022739652 @default.
- W2012135018 creator A5024018167 @default.
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- W2012135018 creator A5057882160 @default.
- W2012135018 creator A5076104674 @default.
- W2012135018 date "2012-03-10" @default.
- W2012135018 modified "2023-09-26" @default.
- W2012135018 title "Low Concentration Microenvironments Enhance the Migration of Neonatal Cells of Glial Lineage" @default.
- W2012135018 cites W1570839422 @default.
- W2012135018 cites W1913428776 @default.
- W2012135018 cites W1967265143 @default.
- W2012135018 cites W1967396842 @default.
- W2012135018 cites W1971503445 @default.
- W2012135018 cites W1979240391 @default.
- W2012135018 cites W1985174260 @default.
- W2012135018 cites W1986758971 @default.
- W2012135018 cites W1987073744 @default.
- W2012135018 cites W1990824001 @default.
- W2012135018 cites W1993860023 @default.
- W2012135018 cites W1994071719 @default.
- W2012135018 cites W1997695178 @default.
- W2012135018 cites W1998007585 @default.
- W2012135018 cites W2002180033 @default.
- W2012135018 cites W2006186019 @default.
- W2012135018 cites W2007382415 @default.
- W2012135018 cites W2008329506 @default.
- W2012135018 cites W2009454668 @default.
- W2012135018 cites W2010346256 @default.
- W2012135018 cites W2010677999 @default.
- W2012135018 cites W2012211657 @default.
- W2012135018 cites W2013669476 @default.
- W2012135018 cites W2019647633 @default.
- W2012135018 cites W2021095320 @default.
- W2012135018 cites W2025504334 @default.
- W2012135018 cites W2027453759 @default.
- W2012135018 cites W2030755036 @default.
- W2012135018 cites W2034898900 @default.
- W2012135018 cites W2035033765 @default.
- W2012135018 cites W2036044314 @default.
- W2012135018 cites W2036164831 @default.
- W2012135018 cites W2036369536 @default.
- W2012135018 cites W2038910312 @default.
- W2012135018 cites W2041813420 @default.
- W2012135018 cites W2044099175 @default.
- W2012135018 cites W2044862408 @default.
- W2012135018 cites W2045810087 @default.
- W2012135018 cites W2047051739 @default.
- W2012135018 cites W2051571748 @default.
- W2012135018 cites W2051916263 @default.
- W2012135018 cites W2057700419 @default.
- W2012135018 cites W2059877177 @default.
- W2012135018 cites W2062279417 @default.
- W2012135018 cites W2062517714 @default.
- W2012135018 cites W2069415454 @default.
- W2012135018 cites W2070655255 @default.
- W2012135018 cites W2076913561 @default.
- W2012135018 cites W2077804275 @default.
- W2012135018 cites W2077818981 @default.
- W2012135018 cites W2079677696 @default.
- W2012135018 cites W2080759640 @default.
- W2012135018 cites W2082376103 @default.
- W2012135018 cites W2083137416 @default.
- W2012135018 cites W2085661751 @default.
- W2012135018 cites W2085760445 @default.
- W2012135018 cites W2095027624 @default.
- W2012135018 cites W2104153100 @default.
- W2012135018 cites W2104917184 @default.
- W2012135018 cites W2105927926 @default.
- W2012135018 cites W2114019259 @default.
- W2012135018 cites W2125521995 @default.
- W2012135018 cites W2125793635 @default.
- W2012135018 cites W2128774344 @default.
- W2012135018 cites W2129269004 @default.
- W2012135018 cites W2129357306 @default.
- W2012135018 cites W2132023472 @default.
- W2012135018 cites W2133138712 @default.
- W2012135018 cites W2137020659 @default.
- W2012135018 cites W2137439281 @default.
- W2012135018 cites W2144908865 @default.
- W2012135018 cites W2149058887 @default.
- W2012135018 cites W2150291313 @default.
- W2012135018 cites W2165200904 @default.
- W2012135018 cites W2166313401 @default.
- W2012135018 cites W2166990204 @default.
- W2012135018 cites W2167648407 @default.
- W2012135018 cites W2168414172 @default.
- W2012135018 cites W38122139 @default.
- W2012135018 cites W4211107382 @default.
- W2012135018 cites W4376596128 @default.
- W2012135018 doi "https://doi.org/10.1007/s12195-012-0226-y" @default.
- W2012135018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3839109" @default.
- W2012135018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24285985" @default.
- W2012135018 hasPublicationYear "2012" @default.
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