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• W2012135264 abstract "Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging.In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of NFkB on miR-222 promoter. Moreover, we demonstrate that miR-222 directly targets CD4, a key receptor for HIV-1, thus reducing its expression. We propose that Tat, by inducing miR-222 expression, complements the CD4 downregulation activity exerted by other viral proteins (i.e., Nef, Vpu, and Env), and we suggest that this represents a novel mechanism through which HIV-1 efficiently represses CD4 expression in infected cells." @default.
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• W2012135264 date "2014-03-06" @default.
• W2012135264 modified "2023-10-17" @default.
• W2012135264 title "The HIV-1 Tat protein modulates CD4 expression in human T cells through the induction of miR-222" @default.
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• W2012135264 doi "https://doi.org/10.4161/rna.28372" @default.
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