Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012135621> ?p ?o ?g. }
- W2012135621 endingPage "147" @default.
- W2012135621 startingPage "138" @default.
- W2012135621 abstract "Invasion of tumor cells is the primary cause of therapeutic failure in malignant chondrosarcomas treatment. Receptor activator of nuclear factor-κB ligand (RANKL) and its receptor, RANK, play a key roles in osteoclastogenesis and tumor metastasis. We found that the RANKL and RANK expression in human chondrosarcoma tissues was higher than that in normal cartilage. We also found that RANKL directed the migration and increased cell surface expression of β1 integrin in human chondrosarcoma cells (JJ012 cells). Pretreatment of JJ012 cells with MAPK kinase (MEK) inhibitors, PD98059 or U0126, inhibited the RANKL-induced migration and integrin expression. Stimulation of cells with RANKL increased the phosphorylation of MEK and extracellular signal-regulating kinase (ERK). In addition, NF-κB inhibitor (PDTC) or IκB protease inhibitor (TPCK) also inhibited RANKL-induced cells migration and integrin up-regulation. Taken together, these results suggest that the RANKL acts through MEK/ERK, which in turn activates IKKα/β and NF-κB, resulting in the activation of β1 integrin and contributing to the migration of human chondrosarcoma cells. J. Cell. Biochem. 111: 138–147, 2010. © 2010 Wiley-Liss, Inc." @default.
- W2012135621 created "2016-06-24" @default.
- W2012135621 creator A5004695493 @default.
- W2012135621 creator A5014801478 @default.
- W2012135621 creator A5046864121 @default.
- W2012135621 creator A5052895838 @default.
- W2012135621 creator A5058015003 @default.
- W2012135621 creator A5069396100 @default.
- W2012135621 creator A5076096342 @default.
- W2012135621 creator A5085507861 @default.
- W2012135621 date "2010-05-12" @default.
- W2012135621 modified "2023-10-16" @default.
- W2012135621 title "Involvement of integrin up-regulation in RANKL/RANK pathway of chondrosarcomas migration" @default.
- W2012135621 cites W1965072143 @default.
- W2012135621 cites W1965404141 @default.
- W2012135621 cites W1968790357 @default.
- W2012135621 cites W1972001482 @default.
- W2012135621 cites W1972414794 @default.
- W2012135621 cites W1984673297 @default.
- W2012135621 cites W1997049126 @default.
- W2012135621 cites W1998392042 @default.
- W2012135621 cites W2005133216 @default.
- W2012135621 cites W2035416199 @default.
- W2012135621 cites W2036285327 @default.
- W2012135621 cites W2038227634 @default.
- W2012135621 cites W2044719350 @default.
- W2012135621 cites W2061144117 @default.
- W2012135621 cites W2063126618 @default.
- W2012135621 cites W2064917907 @default.
- W2012135621 cites W2071352435 @default.
- W2012135621 cites W2081242185 @default.
- W2012135621 cites W2086511139 @default.
- W2012135621 cites W2090644462 @default.
- W2012135621 cites W2093252878 @default.
- W2012135621 cites W2093921289 @default.
- W2012135621 cites W2116426583 @default.
- W2012135621 cites W2135945960 @default.
- W2012135621 cites W2139063456 @default.
- W2012135621 cites W2156581417 @default.
- W2012135621 cites W2157942810 @default.
- W2012135621 cites W2158481098 @default.
- W2012135621 cites W2160271093 @default.
- W2012135621 cites W4255358151 @default.
- W2012135621 cites W4255941290 @default.
- W2012135621 cites W4376848667 @default.
- W2012135621 doi "https://doi.org/10.1002/jcb.22677" @default.
- W2012135621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20506523" @default.
- W2012135621 hasPublicationYear "2010" @default.
- W2012135621 type Work @default.
- W2012135621 sameAs 2012135621 @default.
- W2012135621 citedByCount "19" @default.
- W2012135621 countsByYear W20121356212012 @default.
- W2012135621 countsByYear W20121356212013 @default.
- W2012135621 countsByYear W20121356212014 @default.
- W2012135621 countsByYear W20121356212015 @default.
- W2012135621 countsByYear W20121356212016 @default.
- W2012135621 countsByYear W20121356212018 @default.
- W2012135621 countsByYear W20121356212020 @default.
- W2012135621 countsByYear W20121356212021 @default.
- W2012135621 countsByYear W20121356212022 @default.
- W2012135621 crossrefType "journal-article" @default.
- W2012135621 hasAuthorship W2012135621A5004695493 @default.
- W2012135621 hasAuthorship W2012135621A5014801478 @default.
- W2012135621 hasAuthorship W2012135621A5046864121 @default.
- W2012135621 hasAuthorship W2012135621A5052895838 @default.
- W2012135621 hasAuthorship W2012135621A5058015003 @default.
- W2012135621 hasAuthorship W2012135621A5069396100 @default.
- W2012135621 hasAuthorship W2012135621A5076096342 @default.
- W2012135621 hasAuthorship W2012135621A5085507861 @default.
- W2012135621 hasConcept C137738243 @default.
- W2012135621 hasConcept C142724271 @default.
- W2012135621 hasConcept C1491633281 @default.
- W2012135621 hasConcept C170493617 @default.
- W2012135621 hasConcept C185592680 @default.
- W2012135621 hasConcept C195687474 @default.
- W2012135621 hasConcept C2776302905 @default.
- W2012135621 hasConcept C2779428903 @default.
- W2012135621 hasConcept C2781249067 @default.
- W2012135621 hasConcept C502942594 @default.
- W2012135621 hasConcept C55493867 @default.
- W2012135621 hasConcept C57074206 @default.
- W2012135621 hasConcept C62478195 @default.
- W2012135621 hasConcept C71924100 @default.
- W2012135621 hasConcept C86803240 @default.
- W2012135621 hasConcept C88045685 @default.
- W2012135621 hasConcept C95444343 @default.
- W2012135621 hasConceptScore W2012135621C137738243 @default.
- W2012135621 hasConceptScore W2012135621C142724271 @default.
- W2012135621 hasConceptScore W2012135621C1491633281 @default.
- W2012135621 hasConceptScore W2012135621C170493617 @default.
- W2012135621 hasConceptScore W2012135621C185592680 @default.
- W2012135621 hasConceptScore W2012135621C195687474 @default.
- W2012135621 hasConceptScore W2012135621C2776302905 @default.
- W2012135621 hasConceptScore W2012135621C2779428903 @default.
- W2012135621 hasConceptScore W2012135621C2781249067 @default.
- W2012135621 hasConceptScore W2012135621C502942594 @default.
- W2012135621 hasConceptScore W2012135621C55493867 @default.
- W2012135621 hasConceptScore W2012135621C57074206 @default.