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• W2012135961 endingPage "056003" @default.
• W2012135961 startingPage "056003" @default.
• W2012135961 abstract "Thrombosis accounts for 80% of deaths in patients with diabetes mellitus. Diabetic patients demonstrate tortuous microvessels and larger than normal platelets. Large platelets are associated with increased platelet activation and thrombosis, but the physical effects of large platelets in the microscale processes of thrombus formation are not clear. Therefore, the objective of this study was to determine the physical effects of mean platelet volume (MPV), mean platelet density (MPD) and vessel tortuosity on platelet activation and thrombus formation in tortuous arterioles. A computational model of the transport, shear-induced activation, collision, adhesion and aggregation of individual platelets was used to simulate platelet interactions and thrombus formation in tortuous arterioles. Our results showed that an increase in MPV resulted in a larger number of activated platelets, though MPD and level of tortuosity made little difference on platelet activation. Platelets with normal MPD yielded the lowest amount of mural thrombus. With platelets of normal MPD, the amount of mural thrombus decreased with increasing level of tortuosity but did not have a simple monotonic relationship with MPV. The physical mechanisms associated with MPV, MPD and arteriole tortuosity play important roles in platelet activation and thrombus formation." @default.
• W2012135961 created "2016-06-24" @default.
• W2012135961 creator A5054753371 @default.
• W2012135961 creator A5058317572 @default.
• W2012135961 date "2013-08-23" @default.
• W2012135961 modified "2023-10-18" @default.
• W2012135961 title "Platelet size and density affect shear-induced thrombus formation in tortuous arterioles" @default.
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• W2012135961 doi "https://doi.org/10.1088/1478-3975/10/5/056003" @default.
• W2012135961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814027" @default.
• W2012135961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23974300" @default.
• W2012135961 hasPublicationYear "2013" @default.
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