FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012137480> ?p ?o ?g. }

• W2012137480 abstract "Objectives: To assess the effectiveness and cost-effectiveness of HealOzone® (CurOzone USA Inc., Ontario, Canada) for the management of pit and fissure caries, and root caries. The complete HealOzone procedure involves the direct application of ozone gas to the caries lesion on the tooth surface, the use of a remineralising solution immediately after application of ozone and the supply of a ‘patient kit’, which consists of toothpaste, oral rinse and oral spray all containing fluoride.Data sources: Electronic databases up to May 2004 (except Conference Papers Index, which were searched up to May 2002).Review methods: A systematic review of the effectiveness of HealOzone for the management of tooth decay was carried out. A systematic review of existing economic evaluations of ozone for dental caries was also planned but no suitable studies were identified. The economic evaluation included in the industry submission was critically appraised and summarised. A Markov model was constructed to explore possible cost-effectiveness aspects of HealOzone in addition to current management of dental caries.Results: Five full-text reports and five studies published as abstracts met the inclusion criteria. The five full-text reports consisted of two randomised controlled trials (RCTs) assessing the use of HealOzone for the management of primary root caries and two doctoral theses of three unpublished randomised trials assessing the use of HealOzone for the management of occlusal caries. Of the abstracts, four assessed the effects of HealOzone for the management of occlusal caries and one the effects of HealOzone for the management of root caries. Overall, the quality of the studies was modest, with many important methodological aspects not reported (e.g. concealment of allocation, blinding procedures, compliance of patients with home treatment). In particular, there were some concerns about the choice of statistical analyses. In most of the full-text studies analyses were undertaken at lesion level, ignoring the clustering of lesions within patients. The nature of the methodological concerns was sufficient to raise doubts about the validity of the included studies’ findings. A quantitative synthesis of results was deemed inappropriate. On the whole, there is not enough evidence from published RCTs on which to judge the effectiveness of ozone for the management of both occlusal and root caries. The perspective adopted for the study was that of the NHS and Personal Social Services. The analysis, carried out over a 5-year period, indicated that treatment using current management plus HealOzone cost more than current management alone for non-cavitated pit and fissure caries (£40.49 versus £24.78), but cost less for non-cavitated root caries (£14.63 versus £21.45). Given the limitations of the calculations these figures should be regarded as illustrative, not definitive. It was not possible to measure health benefits in terms of quality-adjusted life-years, due to uncertainties around the evidence of clinical effectiveness, and to the fact that the adverse events avoided are transient (e.g. pain from injection of local anaesthetic, fear of the drill). One-way sensitivity analysis was applied to the model. However, owing to the limitations of the economic analysis, this should be regarded as merely speculative. For non-cavitated pit and fissure caries, the HealOzone option was always more expensive than current management when the probability of cure using the HealOzone option was 70% or lower. For non-cavitated root caries the costs of the HealOzone comparator were lower than those of current management only when cure rates from HealOzone were at least 80%. The costs of current management were higher than those of the HealOzone option when the cure rate for current management was 40% or lower. One-way sensitivity analysis was also performed using similar NHS Statement of Dental Remuneration codes to those that are used in the industry submission. This did not alter the results for non-cavitated pit fissure caries as the discounted net present value of current management remained lower than that of the HealOzone comparator (£22.65 versus £33.39).Conclusions: Any treatment that preserves teeth and avoids fillings is welcome. However, the current evidence base for HealOzone is insufficient to conclude that it is a cost-effective addition to the management and treatment of occlusal and root caries. To make a decision on whether HealOzone is a cost-effective alternative to current preventive methods for the management of dental caries, further research into its clinical effectiveness is required. Independent RCTs of the effectiveness and cost-effectiveness of HealOzone for the management of occlusal caries and root caries need to be properly conducted with adequate design, outcome measures and methods for statistical analyses." @default.
• W2012137480 created "2016-06-24" @default.
• W2012137480 creator A5002556668 @default.
• W2012137480 creator A5038592965 @default.
• W2012137480 creator A5068981280 @default.
• W2012137480 creator A5075679046 @default.
• W2012137480 creator A5080292819 @default.
• W2012137480 creator A5081974212 @default.
• W2012137480 creator A5084883597 @default.
• W2012137480 date "2006-05-01" @default.
• W2012137480 modified "2023-10-11" @default.
• W2012137480 title "Systematic review of the effectiveness and cost-effectiveness of HealOzone® for the treatment of occlusal pit/fissure caries and root caries" @default.
• W2012137480 doi "https://doi.org/10.3310/hta10160" @default.
• W2012137480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16707073" @default.
• W2012137480 hasPublicationYear "2006" @default.
• W2012137480 type Work @default.
• W2012137480 sameAs 2012137480 @default.
• W2012137480 citedByCount "48" @default.
• W2012137480 countsByYear W20121374802012 @default.
• W2012137480 countsByYear W20121374802013 @default.
• W2012137480 countsByYear W20121374802014 @default.
• W2012137480 countsByYear W20121374802015 @default.
• W2012137480 countsByYear W20121374802016 @default.
• W2012137480 countsByYear W20121374802018 @default.
• W2012137480 countsByYear W20121374802019 @default.
• W2012137480 countsByYear W20121374802020 @default.
• W2012137480 countsByYear W20121374802021 @default.
• W2012137480 countsByYear W20121374802022 @default.
• W2012137480 crossrefType "journal-article" @default.
• W2012137480 hasAuthorship W2012137480A5002556668 @default.
• W2012137480 hasAuthorship W2012137480A5038592965 @default.
• W2012137480 hasAuthorship W2012137480A5068981280 @default.
• W2012137480 hasAuthorship W2012137480A5075679046 @default.
• W2012137480 hasAuthorship W2012137480A5080292819 @default.
• W2012137480 hasAuthorship W2012137480A5081974212 @default.
• W2012137480 hasAuthorship W2012137480A5084883597 @default.
• W2012137480 hasBestOaLocation W20121374801 @default.
• W2012137480 hasConcept C166957645 @default.
• W2012137480 hasConcept C199343813 @default.
• W2012137480 hasConcept C2780749890 @default.
• W2012137480 hasConcept C29694066 @default.
• W2012137480 hasConcept C3020334819 @default.
• W2012137480 hasConcept C71924100 @default.
• W2012137480 hasConcept C95457728 @default.
• W2012137480 hasConceptScore W2012137480C166957645 @default.
• W2012137480 hasConceptScore W2012137480C199343813 @default.
• W2012137480 hasConceptScore W2012137480C2780749890 @default.
• W2012137480 hasConceptScore W2012137480C29694066 @default.
• W2012137480 hasConceptScore W2012137480C3020334819 @default.
• W2012137480 hasConceptScore W2012137480C71924100 @default.
• W2012137480 hasConceptScore W2012137480C95457728 @default.
• W2012137480 hasFunder F4320334661 @default.
• W2012137480 hasIssue "16" @default.
• W2012137480 hasLocation W20121374801 @default.
• W2012137480 hasLocation W20121374802 @default.
• W2012137480 hasLocation W20121374803 @default.
• W2012137480 hasLocation W20121374804 @default.
• W2012137480 hasOpenAccess W2012137480 @default.
• W2012137480 hasPrimaryLocation W20121374801 @default.
• W2012137480 hasRelatedWork W2012137480 @default.
• W2012137480 hasRelatedWork W2117144907 @default.
• W2012137480 hasRelatedWork W2317141145 @default.
• W2012137480 hasRelatedWork W2319992129 @default.
• W2012137480 hasRelatedWork W2348889452 @default.
• W2012137480 hasRelatedWork W2355959071 @default.
• W2012137480 hasRelatedWork W2415005815 @default.
• W2012137480 hasRelatedWork W2419570516 @default.
• W2012137480 hasRelatedWork W2954789769 @default.
• W2012137480 hasRelatedWork W177036055 @default.
• W2012137480 hasVolume "10" @default.
• W2012137480 isParatext "false" @default.
• W2012137480 isRetracted "false" @default.
• W2012137480 magId "2012137480" @default.
• W2012137480 workType "article" @default.