Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012137739> ?p ?o ?g. }
- W2012137739 endingPage "566" @default.
- W2012137739 startingPage "557" @default.
- W2012137739 abstract "Methylphenidate is the most commonly prescribed drug for the treatment of ADHD. We have used positron emission tomography to assess the role that methylphenidate's effects in brain dopamine have on its therapeutic and reinforcing effects. We have documented that in the human brain therapeutic doses of methylphenidate block more than 50% of the dopamine transporters and significantly enhance extracellular DA, an effect that appears to be modulated by the rate of DA release. Thus, we postulate that methylphenidate's therapeutic effects are in part due to amplification of DA signals, that variability in responses is in part due to differences in DA tone and that methylphenidate's effects are context dependent. Methylphenidate-induced increases in DA are also associated with its reinforcing effects but only when this occurs rapidly, as with intravenous administration. Moreover, abuse of methylphenidate is constrained by its long half-life, which we postulate limits the frequency at which it can be administered." @default.
- W2012137739 created "2016-06-24" @default.
- W2012137739 creator A5002969658 @default.
- W2012137739 date "2002-12-01" @default.
- W2012137739 modified "2023-09-28" @default.
- W2012137739 title "Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies" @default.
- W2012137739 cites W1437706893 @default.
- W2012137739 cites W1565970281 @default.
- W2012137739 cites W1599894749 @default.
- W2012137739 cites W167546516 @default.
- W2012137739 cites W171691018 @default.
- W2012137739 cites W1967935578 @default.
- W2012137739 cites W1968575533 @default.
- W2012137739 cites W1970090640 @default.
- W2012137739 cites W1970373428 @default.
- W2012137739 cites W1977634040 @default.
- W2012137739 cites W1979792701 @default.
- W2012137739 cites W1980606678 @default.
- W2012137739 cites W1985400908 @default.
- W2012137739 cites W1988174896 @default.
- W2012137739 cites W1990494131 @default.
- W2012137739 cites W1991162436 @default.
- W2012137739 cites W2001355988 @default.
- W2012137739 cites W2003122586 @default.
- W2012137739 cites W2006715508 @default.
- W2012137739 cites W2008388130 @default.
- W2012137739 cites W2014793858 @default.
- W2012137739 cites W2015104943 @default.
- W2012137739 cites W20185869 @default.
- W2012137739 cites W2029474372 @default.
- W2012137739 cites W2033200028 @default.
- W2012137739 cites W2036466635 @default.
- W2012137739 cites W2041080698 @default.
- W2012137739 cites W2043172501 @default.
- W2012137739 cites W2047648732 @default.
- W2012137739 cites W2048280165 @default.
- W2012137739 cites W2056319469 @default.
- W2012137739 cites W2057683939 @default.
- W2012137739 cites W2062714266 @default.
- W2012137739 cites W2070796637 @default.
- W2012137739 cites W2070816708 @default.
- W2012137739 cites W2077150252 @default.
- W2012137739 cites W2077620252 @default.
- W2012137739 cites W2077707065 @default.
- W2012137739 cites W2078811235 @default.
- W2012137739 cites W2079679654 @default.
- W2012137739 cites W2082888727 @default.
- W2012137739 cites W2085038977 @default.
- W2012137739 cites W2086016890 @default.
- W2012137739 cites W2087188715 @default.
- W2012137739 cites W2089436261 @default.
- W2012137739 cites W2091680463 @default.
- W2012137739 cites W2095217951 @default.
- W2012137739 cites W2095875127 @default.
- W2012137739 cites W2096943304 @default.
- W2012137739 cites W2098677721 @default.
- W2012137739 cites W2111065019 @default.
- W2012137739 cites W2112098409 @default.
- W2012137739 cites W2114207481 @default.
- W2012137739 cites W2116795024 @default.
- W2012137739 cites W2117808207 @default.
- W2012137739 cites W2122694895 @default.
- W2012137739 cites W2123353332 @default.
- W2012137739 cites W2127107429 @default.
- W2012137739 cites W2128211763 @default.
- W2012137739 cites W2135248098 @default.
- W2012137739 cites W2139591064 @default.
- W2012137739 cites W2141536473 @default.
- W2012137739 cites W2141678890 @default.
- W2012137739 cites W2160228470 @default.
- W2012137739 cites W2172219495 @default.
- W2012137739 cites W2240581719 @default.
- W2012137739 cites W2395709394 @default.
- W2012137739 cites W2417375048 @default.
- W2012137739 cites W2418050700 @default.
- W2012137739 cites W2418762256 @default.
- W2012137739 cites W2998211837 @default.
- W2012137739 cites W637998496 @default.
- W2012137739 doi "https://doi.org/10.1016/s0924-977x(02)00104-9" @default.
- W2012137739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12468018" @default.
- W2012137739 hasPublicationYear "2002" @default.
- W2012137739 type Work @default.
- W2012137739 sameAs 2012137739 @default.
- W2012137739 citedByCount "188" @default.
- W2012137739 countsByYear W20121377392012 @default.
- W2012137739 countsByYear W20121377392013 @default.
- W2012137739 countsByYear W20121377392014 @default.
- W2012137739 countsByYear W20121377392015 @default.
- W2012137739 countsByYear W20121377392016 @default.
- W2012137739 countsByYear W20121377392017 @default.
- W2012137739 countsByYear W20121377392018 @default.
- W2012137739 countsByYear W20121377392019 @default.
- W2012137739 countsByYear W20121377392020 @default.
- W2012137739 countsByYear W20121377392021 @default.
- W2012137739 countsByYear W20121377392022 @default.
- W2012137739 countsByYear W20121377392023 @default.
- W2012137739 crossrefType "journal-article" @default.
- W2012137739 hasAuthorship W2012137739A5002969658 @default.