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• W2012138617 abstract "Human platelets prelabeled with [3H]inositol were exposed to thrombin. The aqueous soluble inositol phosphates were separated by anion exchange column chromatography, paper chromatography or high-performance liquid chromatography, and identified by cochromatography with authentic standard substances. Thrombin immediately induces the rapid formation of inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate. Accumulation of inositol-1-monophosphate and inositol-2-monophosphate occurs later after a time lag of 10 sec. The results indicate that the phospholipase C induced polyphosphoinositide hydrolysis rather than the phosphatidylinositol hydrolysis is the triggering event for platelet activation, and support the concept of inositol 1,4,5-trisphosphate as putative second messenger." @default.
• W2012138617 created "2016-06-24" @default.
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• W2012138617 creator A5015808933 @default.
• W2012138617 date "1985-01-21" @default.
• W2012138617 modified "2023-09-25" @default.
• W2012138617 title "Thrombin induces the rapid formation of inositol bisphosphate and inositol trisphosphate in human platelets" @default.
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• W2012138617 doi "https://doi.org/10.1016/0014-5793(85)80241-6" @default.
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