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- W2012139691 abstract "A large number of functionally substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence of ICl to give the corresponding 4-iodoisoxazoles in moderate to excellent yields. The resulting 4-iodoisoxazoles undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles, including valdecoxib." @default.
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- W2012139691 date "2007-11-03" @default.
- W2012139691 modified "2023-10-02" @default.
- W2012139691 title "The Synthesis of Highly Substituted Isoxazoles by Electrophilic Cyclization: An Efficient Synthesis of Valdecoxib" @default.
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- W2012139691 doi "https://doi.org/10.1021/jo701942e" @default.
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