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- W2012143564 abstract "Human papillomaviruses (HPVs), with over 100 genotypes, are a very complex group of human pathogenic viruses. In most cases, HPV infection results in benign epithelial proliferations (verrucae). However, oncogenic types of HPV may induce malignant transformation in the presence of cofactors. For example, over 99% of all cervical cancers and a majority of vulval, vaginal, anal and penile cancers are the result of oncogenic HPV types. Such HPV types have been increasingly linked to other epithelial cancers involving the skin, larynx and oesophagus. Although viral infection is necessary for neoplastic transformation, evidence suggests that host and environmental cofactors are also required. Research investigating HPV oncogenesis is complex and quite extensive. The inability to produce mature HPV virions in animal models has been a major limitation in fully elucidating the oncogenic potential and role of associated cofactors in promoting malignant transformation in HPV-infected cells. We have reviewed the literature and provide a brief account of the current understanding of HPV oncogenesis, emphasizing the role of genetic susceptibility, immune response, and environmental and infectious cofactors." @default.
- W2012143564 created "2016-06-24" @default.
- W2012143564 creator A5032853375 @default.
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- W2012143564 date "2007-08-01" @default.
- W2012143564 modified "2023-10-14" @default.
- W2012143564 title "The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors" @default.
- W2012143564 cites W109836713 @default.
- W2012143564 cites W1492857769 @default.
- W2012143564 cites W1522687886 @default.
- W2012143564 cites W1582161103 @default.
- W2012143564 cites W1595390099 @default.
- W2012143564 cites W1640433995 @default.
- W2012143564 cites W1643155728 @default.
- W2012143564 cites W1881144545 @default.
- W2012143564 cites W1967960141 @default.
- W2012143564 cites W1970073011 @default.
- W2012143564 cites W1971749273 @default.
- W2012143564 cites W1971766117 @default.
- W2012143564 cites W1971917499 @default.
- W2012143564 cites W1973311422 @default.
- W2012143564 cites W1973624321 @default.
- W2012143564 cites W1974120307 @default.
- W2012143564 cites W1976594887 @default.
- W2012143564 cites W1977523857 @default.
- W2012143564 cites W1978406229 @default.
- W2012143564 cites W1979851138 @default.
- W2012143564 cites W1984061101 @default.
- W2012143564 cites W1987704649 @default.
- W2012143564 cites W1992403141 @default.
- W2012143564 cites W1994821015 @default.
- W2012143564 cites W2000181047 @default.
- W2012143564 cites W2001789976 @default.
- W2012143564 cites W2004342441 @default.
- W2012143564 cites W2005030689 @default.
- W2012143564 cites W2009224373 @default.
- W2012143564 cites W2013672350 @default.
- W2012143564 cites W2016378791 @default.
- W2012143564 cites W2017135411 @default.
- W2012143564 cites W2017488658 @default.
- W2012143564 cites W2019980953 @default.
- W2012143564 cites W2021004485 @default.
- W2012143564 cites W2022305813 @default.
- W2012143564 cites W2023714130 @default.
- W2012143564 cites W2025638244 @default.
- W2012143564 cites W2025842054 @default.
- W2012143564 cites W2033143680 @default.
- W2012143564 cites W2033907978 @default.
- W2012143564 cites W2035073821 @default.
- W2012143564 cites W2035602039 @default.
- W2012143564 cites W2036091927 @default.
- W2012143564 cites W2037412054 @default.
- W2012143564 cites W2042766700 @default.
- W2012143564 cites W2044453012 @default.
- W2012143564 cites W2048324377 @default.
- W2012143564 cites W2048376669 @default.
- W2012143564 cites W2050512563 @default.
- W2012143564 cites W2052489835 @default.
- W2012143564 cites W2057635945 @default.
- W2012143564 cites W2059459612 @default.
- W2012143564 cites W2060328277 @default.
- W2012143564 cites W2063173033 @default.
- W2012143564 cites W2063465744 @default.
- W2012143564 cites W2063548946 @default.
- W2012143564 cites W2063806298 @default.
- W2012143564 cites W2064008506 @default.
- W2012143564 cites W2065298839 @default.
- W2012143564 cites W2066119742 @default.
- W2012143564 cites W2068319647 @default.
- W2012143564 cites W2068582192 @default.
- W2012143564 cites W2070912899 @default.
- W2012143564 cites W2072667169 @default.
- W2012143564 cites W2073827692 @default.
- W2012143564 cites W2074888068 @default.
- W2012143564 cites W2076694631 @default.
- W2012143564 cites W2076926089 @default.
- W2012143564 cites W2077197239 @default.
- W2012143564 cites W2079128321 @default.
- W2012143564 cites W2080279220 @default.
- W2012143564 cites W2082883130 @default.
- W2012143564 cites W2082904105 @default.
- W2012143564 cites W2084509222 @default.
- W2012143564 cites W2084931539 @default.
- W2012143564 cites W2085976263 @default.
- W2012143564 cites W2087019729 @default.
- W2012143564 cites W2087483967 @default.
- W2012143564 cites W2089348790 @default.
- W2012143564 cites W2094440824 @default.
- W2012143564 cites W2094529863 @default.
- W2012143564 cites W2095976339 @default.
- W2012143564 cites W2098925859 @default.
- W2012143564 cites W2101196984 @default.
- W2012143564 cites W2105496972 @default.
- W2012143564 cites W2113290984 @default.