FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012144021> ?p ?o ?g. }

• W2012144021 endingPage "218" @default.
• W2012144021 startingPage "210" @default.
• W2012144021 abstract "Gadolinium (Gd) contrast agents are predominantly used for T1 MR imaging. However, the high toxicity of Gd3 + and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T1 magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T1 MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers." @default.
• W2012144021 created "2016-06-24" @default.
• W2012144021 creator A5011327051 @default.
• W2012144021 creator A5046228645 @default.
• W2012144021 creator A5060235209 @default.
• W2012144021 creator A5080427926 @default.
• W2012144021 creator A5084051485 @default.
• W2012144021 creator A5089465392 @default.
• W2012144021 creator A5080020710 @default.
• W2012144021 date "2013-04-01" @default.
• W2012144021 modified "2023-10-01" @default.
• W2012144021 title "Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs" @default.
• W2012144021 cites W1964796862 @default.
• W2012144021 cites W1969043349 @default.
• W2012144021 cites W1970024572 @default.
• W2012144021 cites W1972531115 @default.
• W2012144021 cites W1973436374 @default.
• W2012144021 cites W1975150426 @default.
• W2012144021 cites W1981199702 @default.
• W2012144021 cites W1987924718 @default.
• W2012144021 cites W1989230986 @default.
• W2012144021 cites W1997617616 @default.
• W2012144021 cites W2002517161 @default.
• W2012144021 cites W2006175906 @default.
• W2012144021 cites W2007040462 @default.
• W2012144021 cites W2024124596 @default.
• W2012144021 cites W2026010038 @default.
• W2012144021 cites W2026387992 @default.
• W2012144021 cites W2034342858 @default.
• W2012144021 cites W2038949845 @default.
• W2012144021 cites W2044522137 @default.
• W2012144021 cites W2045555378 @default.
• W2012144021 cites W2081013313 @default.
• W2012144021 cites W2089399905 @default.
• W2012144021 cites W2090171454 @default.
• W2012144021 cites W2091531732 @default.
• W2012144021 cites W2106821617 @default.
• W2012144021 cites W2107169773 @default.
• W2012144021 cites W2112932690 @default.
• W2012144021 cites W2115823017 @default.
• W2012144021 cites W2116402747 @default.
• W2012144021 cites W2118969052 @default.
• W2012144021 cites W2126346850 @default.
• W2012144021 cites W2127279078 @default.
• W2012144021 cites W2128319320 @default.
• W2012144021 cites W2136487808 @default.
• W2012144021 cites W2139702993 @default.
• W2012144021 cites W2157646788 @default.
• W2012144021 cites W2171384411 @default.
• W2012144021 doi "https://doi.org/10.1016/j.jconrel.2013.01.029" @default.
• W2012144021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3783961" @default.
• W2012144021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23395689" @default.
• W2012144021 hasPublicationYear "2013" @default.
• W2012144021 type Work @default.
• W2012144021 sameAs 2012144021 @default.
• W2012144021 citedByCount "47" @default.
• W2012144021 countsByYear W20121440212013 @default.
• W2012144021 countsByYear W20121440212014 @default.
• W2012144021 countsByYear W20121440212015 @default.
• W2012144021 countsByYear W20121440212016 @default.
• W2012144021 countsByYear W20121440212017 @default.
• W2012144021 countsByYear W20121440212018 @default.
• W2012144021 countsByYear W20121440212019 @default.
• W2012144021 countsByYear W20121440212020 @default.
• W2012144021 countsByYear W20121440212021 @default.
• W2012144021 countsByYear W20121440212022 @default.
• W2012144021 countsByYear W20121440212023 @default.
• W2012144021 crossrefType "journal-article" @default.
• W2012144021 hasAuthorship W2012144021A5011327051 @default.
• W2012144021 hasAuthorship W2012144021A5046228645 @default.
• W2012144021 hasAuthorship W2012144021A5060235209 @default.
• W2012144021 hasAuthorship W2012144021A5080020710 @default.
• W2012144021 hasAuthorship W2012144021A5080427926 @default.
• W2012144021 hasAuthorship W2012144021A5084051485 @default.
• W2012144021 hasAuthorship W2012144021A5089465392 @default.
• W2012144021 hasBestOaLocation W20121440212 @default.
• W2012144021 hasConcept C121332964 @default.
• W2012144021 hasConcept C12554922 @default.
• W2012144021 hasConcept C150903083 @default.
• W2012144021 hasConcept C178790620 @default.
• W2012144021 hasConcept C18150654 @default.
• W2012144021 hasConcept C185592680 @default.
• W2012144021 hasConcept C202751555 @default.
• W2012144021 hasConcept C207001950 @default.
• W2012144021 hasConcept C2776964284 @default.
• W2012144021 hasConcept C2778978742 @default.
• W2012144021 hasConcept C2779820397 @default.
• W2012144021 hasConcept C46141821 @default.
• W2012144021 hasConcept C55493867 @default.
• W2012144021 hasConcept C557651011 @default.
• W2012144021 hasConcept C86803240 @default.
• W2012144021 hasConceptScore W2012144021C121332964 @default.
• W2012144021 hasConceptScore W2012144021C12554922 @default.
• W2012144021 hasConceptScore W2012144021C150903083 @default.
• W2012144021 hasConceptScore W2012144021C178790620 @default.
• W2012144021 hasConceptScore W2012144021C18150654 @default.
• W2012144021 hasConceptScore W2012144021C185592680 @default.
• W2012144021 hasConceptScore W2012144021C202751555 @default.

• next