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• W2012144319 abstract "In vivo reconstitution of the TDP-l-megosamine pathway from the megalomicin gene cluster of Micromonospora megalomicea was accomplished by the heterologous expression of its biosynthetic genes in Escherichia coli. Mass spectrometric analysis of the TDP-sugar intermediates produced from operons containing different sets of genes showed that the production of TDP-l-megosamine from TDP-4-keto-6-deoxy-d-glucose requires only five biosynthetic steps, catalyzed by MegBVI, MegDII, MegDIII, MegDIV, and MegDV. Bioconversion studies demonstrated that the sugar transferase MegDI, along with the helper protein MegDVI, catalyzes the transfer of l-megosamine to either erythromycin C or erythromycin D, suggesting two possible routes for the production of megalomicin A. Analysis in vivo of the hydroxylation step by MegK indicated that erythromycin C is the intermediate of megalomicin A biosynthesis." @default.
• W2012144319 created "2016-06-24" @default.
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• W2012144319 date "2010-06-15" @default.
• W2012144319 modified "2023-10-16" @default.
• W2012144319 title "TDP- <scp>l</scp> -Megosamine Biosynthesis Pathway Elucidation and Megalomicin A Production in <i>Escherichia coli</i>" @default.
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• W2012144319 doi "https://doi.org/10.1128/aem.03083-09" @default.
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