Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012144927> ?p ?o ?g. }
- W2012144927 endingPage "615" @default.
- W2012144927 startingPage "609" @default.
- W2012144927 abstract "Purpose of review Asymmetric dimethylarginine (ADMA) is a naturally occurring amino acid that reduces the bioavailability of nitric oxide. ADMA opposes important antiatherosclerotic effects of nitric oxide. ADMA not only correlates with traditional and nontraditional risk factors but is also considered a common pathway mediating the adverse vascular effects of traditional and nontraditional risk factors. Over the past 15 years, ADMA has generated increasing interest from both clinical scientist and basic researchers. The present study summarizes the latest developments in the field. Recent findings Modulating (increasing) activity of dimethylamine dimethylaminohydrolase, the main enzyme metabolizing ADMA, emerges as a possible therapeutic option to lower ADMA and favorably influence organ dysfunction. These preclinical findings are thought to be of major importance as ADMA predicts cardiovascular events and mortality in the general population and in patients with chronic kidney disease. Also, ADMA uniformly predicts the progression of moderate and severe chronic kidney disease. Symmetrical dimethylarginine, the structural isomer of ADMA, which was mistakenly thought to be without biological relevance, indicates the degree of renal impairment. Summary ADMA also beautifully explains many facets of the pathophysiology of chronic kidney disease. Future preclinical and especially clinical studies are required to prove the importance of ADMA in renal and cardiovascular disease." @default.
- W2012144927 created "2016-06-24" @default.
- W2012144927 creator A5019459931 @default.
- W2012144927 creator A5051761992 @default.
- W2012144927 date "2008-11-01" @default.
- W2012144927 modified "2023-10-18" @default.
- W2012144927 title "Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease" @default.
- W2012144927 cites W1209933684 @default.
- W2012144927 cites W1500258918 @default.
- W2012144927 cites W1521989421 @default.
- W2012144927 cites W1966974420 @default.
- W2012144927 cites W1971310902 @default.
- W2012144927 cites W1972977589 @default.
- W2012144927 cites W1975521806 @default.
- W2012144927 cites W1977404060 @default.
- W2012144927 cites W1979761529 @default.
- W2012144927 cites W1980849072 @default.
- W2012144927 cites W1981268963 @default.
- W2012144927 cites W1983303842 @default.
- W2012144927 cites W1987580074 @default.
- W2012144927 cites W1989697162 @default.
- W2012144927 cites W1994223673 @default.
- W2012144927 cites W1995130614 @default.
- W2012144927 cites W1998205437 @default.
- W2012144927 cites W2000796869 @default.
- W2012144927 cites W2004688216 @default.
- W2012144927 cites W2004848147 @default.
- W2012144927 cites W2007685359 @default.
- W2012144927 cites W2008201148 @default.
- W2012144927 cites W2037110611 @default.
- W2012144927 cites W2037655806 @default.
- W2012144927 cites W2037709367 @default.
- W2012144927 cites W2050503146 @default.
- W2012144927 cites W2053834273 @default.
- W2012144927 cites W2053959062 @default.
- W2012144927 cites W2055136499 @default.
- W2012144927 cites W2058385357 @default.
- W2012144927 cites W2060858381 @default.
- W2012144927 cites W2073133399 @default.
- W2012144927 cites W2080760372 @default.
- W2012144927 cites W2089313777 @default.
- W2012144927 cites W2098154479 @default.
- W2012144927 cites W2099988883 @default.
- W2012144927 cites W2101447446 @default.
- W2012144927 cites W2105082749 @default.
- W2012144927 cites W2106422918 @default.
- W2012144927 cites W2107017556 @default.
- W2012144927 cites W2112439550 @default.
- W2012144927 cites W2115001982 @default.
- W2012144927 cites W2115421882 @default.
- W2012144927 cites W2117157033 @default.
- W2012144927 cites W2119177204 @default.
- W2012144927 cites W2119790468 @default.
- W2012144927 cites W2119861336 @default.
- W2012144927 cites W2121391159 @default.
- W2012144927 cites W2124279221 @default.
- W2012144927 cites W2129050578 @default.
- W2012144927 cites W2132464590 @default.
- W2012144927 cites W2134310604 @default.
- W2012144927 cites W2140217457 @default.
- W2012144927 cites W2145802142 @default.
- W2012144927 cites W2146571493 @default.
- W2012144927 cites W2148531805 @default.
- W2012144927 cites W2150078273 @default.
- W2012144927 cites W2151296579 @default.
- W2012144927 cites W2151555731 @default.
- W2012144927 cites W2153110646 @default.
- W2012144927 cites W2154975997 @default.
- W2012144927 cites W2161601552 @default.
- W2012144927 cites W2165836510 @default.
- W2012144927 cites W2166937516 @default.
- W2012144927 cites W2167819784 @default.
- W2012144927 cites W2330866082 @default.
- W2012144927 cites W2062801753 @default.
- W2012144927 doi "https://doi.org/10.1097/mnh.0b013e328314b6ca" @default.
- W2012144927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18941355" @default.
- W2012144927 hasPublicationYear "2008" @default.
- W2012144927 type Work @default.
- W2012144927 sameAs 2012144927 @default.
- W2012144927 citedByCount "61" @default.
- W2012144927 countsByYear W20121449272012 @default.
- W2012144927 countsByYear W20121449272013 @default.
- W2012144927 countsByYear W20121449272014 @default.
- W2012144927 countsByYear W20121449272015 @default.
- W2012144927 countsByYear W20121449272016 @default.
- W2012144927 countsByYear W20121449272019 @default.
- W2012144927 countsByYear W20121449272021 @default.
- W2012144927 countsByYear W20121449272022 @default.
- W2012144927 countsByYear W20121449272023 @default.
- W2012144927 crossrefType "journal-article" @default.
- W2012144927 hasAuthorship W2012144927A5019459931 @default.
- W2012144927 hasAuthorship W2012144927A5051761992 @default.
- W2012144927 hasConcept C10162356 @default.
- W2012144927 hasConcept C126322002 @default.
- W2012144927 hasConcept C2777468819 @default.
- W2012144927 hasConcept C2778653478 @default.
- W2012144927 hasConcept C2779134260 @default.
- W2012144927 hasConcept C2779877776 @default.